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aagr-1 P-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177632, updated on 12-Jun-2024

Summary

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Gene symbol
aagr-1
Gene description
P-type domain-containing protein
Locus tag
CELE_D2096.3
See related
AllianceGenome:WB:WBGene00017071
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables alpha-1,4-glucosidase activity. Involved in glycogen catabolic process. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in glycogen storage disease II. Orthologous to several human genes including MGAM (maltase-glucoamylase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See aagr-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
16
Sequence:
Chromosome: IV; NC_003282.8 (8366750..8375371)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene DDE-1 domain-containing protein;ELYS domain-containing protein;FA_FANCE domain-containing protein;Uncharacterized protein Neighboring gene Nucleosome assembly protein 1-like 1 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bioinformatic and biochemical studies point to AAGR-1 as the ortholog of human acid alpha-glucosidase in Caenorhabditis elegans. Sikora J, et al. Mol Cell Biochem, 2010 Aug. PMID 20349118
  2. SKIP and BIR-1/Survivin have potential to integrate proteome status with gene expression. Kostrouch D, et al. J Proteomics, 2014 Oct 14. PMID 25088050
  3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. acid-active AAGR-1 (D2096.3) may represent the ortholog of human acid alpha-glucosidase in C. elegans
    Title: Bioinformatic and biochemical studies point to AAGR-1 as the ortholog of human acid alpha-glucosidase in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables alpha-1,4-glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-1,4-glucosidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables alpha-glucosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
P-type domain-containing protein
NP_501419.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8366750..8375371
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069018.8 → NP_501419.2  P-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501419.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19004
    Conserved Domains (4) summary
    smart00018
    Location:24 → 70
    PD; P or trefoil or TFF domain
    cd06602
    Location:299 → 691
    GH31_MGAM_SI_GAA; maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase
    cd14752
    Location:186 → 299
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    pfam16863
    Location:72 → 186
    NtCtMGAM_N; N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase
Nucleotide Protein
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