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spk-1 Serine/threonine-protein kinase spk-1;non-specific serine/threonine protein kinase [ Caenorhabditis elegans ]

Gene ID: 176328, updated on 18-Sep-2024

Summary

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Official Symbol
spk-1
Official Full Name
Serine/threonine-protein kinase spk-1;non-specific serine/threonine protein kinase
Primary source
WormBase:WBGene00004980
Locus tag
CELE_B0464.5
See related
AllianceGenome:WB:WBGene00004980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein serine/threonine kinase activity. Involved in embryo development and protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including hypodermis; intestine; nervous system; pharyngeal-intestinal valve; and reproductive system. Orthologous to several human genes including SRPK2 (SRSF protein kinase 2) and SRPK3 (SRSF protein kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
12
Sequence:
Chromosome: III; NC_003281.10 (9456608..9463007)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene AH domain-containing protein Neighboring gene GTP-binding protein Rheb homolog 1 Neighboring gene Uncharacterized protein Neighboring gene putative protein phosphatase methylesterase 1 Neighboring gene Barrier-to-autointegration factor 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Alternative 3' UTR selection controls PAR-5 homeostasis and cell polarity in C. elegans embryos. Mikl M, et al. Cell Rep, 2014 Sep 11. PMID 25199833
  2. SPK-1, an SR protein kinase, inhibits programmed cell death in Caenorhabditis elegans. Galvin BD, et al. Proc Natl Acad Sci U S A, 2011 Feb 1. PMID 21245325, Free PMC Article
  3. SPK-1, a C. elegans SR protein kinase homologue, is essential for embryogenesis and required for germline development. Kuroyanagi H, et al. Mech Dev, 2000 Dec. PMID 11091073
  4. Functional characterization of SR and SR-related genes in Caenorhabditis elegans. Longman D, et al. EMBO J, 2000 Apr 3. PMID 10747030, Free PMC Article
  5. Alternative chaperone machinery may compensate for calreticulin/calnexin deficiency in Caenorhabditis elegans. Lee W, et al. Proteomics, 2006 Feb. PMID 16404716

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in embryo development ending in birth or egg hatching IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spliceosomal complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Serine/threonine-protein kinase spk-1;non-specific serine/threonine protein kinase
NP_001021133.1
  • Confirmed by transcript evidence
NP_001021134.1
  • Partially confirmed by transcript evidence
NP_001293645.1
  • Confirmed by transcript evidence
NP_499080.3
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    9456608..9463007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001025963.6 → NP_001021134.1  Serine/threonine-protein kinase spk-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021134.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q03563
    Conserved Domains (2) summary
    smart00220
    Location:134 → 284
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:123 → 675
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001025962.3 → NP_001021133.1  Serine/threonine-protein kinase spk-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021133.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q03563
    Conserved Domains (2) summary
    smart00220
    Location:134 → 616
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14136
    Location:123 → 616
    STKc_SRPK; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase

  3. NM_066679.5 → NP_499080.3  Serine/threonine-protein kinase spk-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499080.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q03563, Q9XVX9, Q9XVY0
    Conserved Domains (2) summary
    smart00220
    Location:422 → 904
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14136
    Location:411 → 904
    STKc_SRPK; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase

  4. NM_001306716.3 → NP_001293645.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293645.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M1ZJY1
    Conserved Domains (1) summary
    cd14136
    Location:27 → 520
    STKc_SRPK; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03563.3

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