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nca-2 Ion transport domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175674, updated on 18-Sep-2024

Summary

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Official Symbol
nca-2
Official Full Name
Ion transport domain-containing protein
Primary source
WormBase:WBGene00003558
Locus tag
CELE_C27F2.2
See related
AllianceGenome:WB:WBGene00003558
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cation channel activity. Involved in positive regulation of GABAergic synaptic transmission; positive regulation of cholinergic synaptic transmission; and positive regulation of locomotion. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including intestine and nervous system. Orthologous to human NALCN (sodium leak channel, non-selective). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
23
Sequence:
Chromosome: III; NC_003281.10 (4965571..4979738)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene JmjC domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Potassium channel domain-containing protein Neighboring gene putative F-box protein C27F2.7 Neighboring gene PCI domain-containing protein 2 homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Corrigendum. . Genetics, 2017 Aug. PMID 28778879, Free PMC Article
  2. De novo missense mutations in NALCN cause developmental and intellectual impairment with hypotonia. Fukai R, et al. J Hum Genet, 2016 May. PMID 26763878
  3. Dopamine negatively modulates the NCA ion channels in C. elegans. Topalidou I, et al. PLoS Genet, 2017 Oct. PMID 28968387, Free PMC Article
  4. The NCA-1 and NCA-2 Ion Channels Function Downstream of G(q) and Rho To Regulate Locomotion in Caenorhabditis elegans. Topalidou I, et al. Genetics, 2017 May. PMID 28325749, Free PMC Article
  5. Action potentials contribute to neuronal signaling in C. elegans. Mellem JE, et al. Nat Neurosci, 2008 Aug. PMID 18587393, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic epistasis experiments suggest that GRK-2 acts on the D2-like dopamine receptor DOP-3 to inhibit Go signaling and positively modulate NCA-1 and NCA-2 activity.
    Title: Dopamine negatively modulates the NCA ion channels in C. elegans.
  2. Our results suggest that NCA-1 and NCA-2 are physiologically relevant targets of neuronal Gq-Rho signaling in C. elegans
    Title: The NCA-1 and NCA-2 Ion Channels Function Downstream of G(q) and Rho To Regulate Locomotion in Caenorhabditis elegans.
  3. UNC-80 is required for the proper localization of the NCA-1 and NCA-2 ion channel subunits.
    Title: UNC-80 and the NCA ion channels contribute to endocytosis defects in synaptojanin mutants.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables monoatomic cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoatomic cation channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of locomotion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of synaptic transmission, GABAergic IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of synaptic transmission, GABAergic IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of synaptic transmission, cholinergic IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of synaptic transmission, cholinergic IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ion transport domain-containing protein
NP_001129835.1
  • Confirmed by transcript evidence
NP_498054.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    4965571..4979738
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065653.6 → NP_498054.2  Ion transport domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498054.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDM1
    Conserved Domains (1) summary
    pfam00520
    Location:1288 → 1518
    Ion_trans; Ion transport protein

  2. NM_001136363.4 → NP_001129835.1  Ion transport domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129835.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EG32
    Conserved Domains (1) summary
    pfam00520
    Location:1266 → 1496
    Ion_trans; Ion transport protein
Nucleotide Protein
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