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depd-5 DEP domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175548, updated on 18-Sep-2024

Summary

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Official Symbol
depd-5
Official Full Name
DEP domain-containing protein
Primary source
WormBase:WBGene00011604
Locus tag
CELE_T08A11.1
See related
AllianceGenome:WB:WBGene00011604
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to contribute to GTPase activator activity. Predicted to be involved in cellular response to amino acid starvation; negative regulation of TOR signaling; and regulation of autophagy. Predicted to be part of GATOR1 complex. Predicted to be active in lysosomal membrane. Is expressed in intestine and nervous system. Human ortholog(s) of this gene implicated in focal epilepsy. Orthologous to human DEPDC5 (DEP domain containing 5, GATOR1 subcomplex subunit). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See depd-5 in Genome Data Viewer
Location:
chromosome: III
Exon count:
17
Sequence:
Chromosome: III; NC_003281.10 (4248152..4263148, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene HIT-type domain-containing protein Neighboring gene WD repeat-containing protein 55 Neighboring gene Splicing factor 3B subunit 1 domain-containing protein Neighboring gene BTB domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813
  2. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
  3. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
  4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to amino acid starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of GATOR1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DEP domain-containing protein
NP_001366728.1
  • Confirmed by transcript evidence
NP_001420380.1
  • Confirmed by transcript evidence
NP_001420381.1
  • Confirmed by transcript evidence
NP_001420382.1
  • Confirmed by transcript evidence
NP_001420383.1
  • Confirmed by transcript evidence
NP_001420384.1
  • Confirmed by transcript evidence
NP_001420385.1
  • Confirmed by transcript evidence
NP_001420386.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    4248152..4263148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001381826.1 → NP_001366728.1  DEP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBK0
    Conserved Domains (2) summary
    smart00049
    Location:1332 → 1418
    DEP; Domain found in Dishevelled, Egl-10, and Pleckstrin
    pfam12257
    Location:214 → 493
    IML1; Vacuolar membrane-associated protein Iml1

  2. NM_001433456.1 → NP_001420385.1  DEP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

  3. NM_001433457.1 → NP_001420380.1  DEP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

  4. NM_001433459.1 → NP_001420382.1  DEP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

  5. NM_001433454.1 → NP_001420383.1  DEP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

  6. NM_001433455.1 → NP_001420381.1  DEP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

  7. NM_001433458.1 → NP_001420384.1  DEP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

  8. NM_001433460.1 → NP_001420386.1  DEP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

Nucleotide Protein
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