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R53.5 Peroxiredoxin-like 2A [ Caenorhabditis elegans ]

Gene ID: 174555, updated on 22-May-2024

Summary

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Gene symbol
R53.5
Gene description
Peroxiredoxin-like 2A
Primary source
WormBase:WBGene00011274
Locus tag
CELE_R53.5
See related
AllianceGenome:WB:WBGene00011274
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable antioxidant activity. Predicted to be involved in cellular oxidant detoxification. Predicted to be active in cytoplasm. Is expressed in several structures, including coelomocyte; head mesodermal cell; intestine; nervous system; and rectal gland cell. Orthologous to human PRXL2A (peroxiredoxin like 2A). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See R53.5 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (9969620..9970488, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Putative ATP synthase subunit f, mitochondrial Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene putative DNA replication complex GINS protein PSF1 Neighboring gene CBS domain-containing protein Neighboring gene AMIN domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
  2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables antioxidant activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Peroxiredoxin-like 2A
NP_496154.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    9969620..9970488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063753.6 → NP_496154.1  Peroxiredoxin-like 2A [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496154.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22020
    Conserved Domains (1) summary
    cd02970
    Location:59 → 196
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
Nucleotide Protein
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