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egl-43 Zinc finger protein egl-43 [ Caenorhabditis elegans ]

Gene ID: 174552, updated on 18-Sep-2024

Summary

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Official Symbol
egl-43
Official Full Name
Zinc finger protein egl-43
Primary source
WormBase:WBGene00001207
Locus tag
CELE_R53.3
See related
AllianceGenome:WB:WBGene00001207
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables DNA-binding transcription factor activity. Involved in several processes, including regulation of cell fate specification; regulation of neuron differentiation; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including MSaaaa; MSaaap; gonad; neurons; and somatic gonad precursor. Human ortholog(s) of this gene implicated in myeloid neoplasm. Orthologous to several human genes including MECOM (MDS1 and EVI1 complex locus). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
9
Sequence:
Chromosome: II; NC_003280.10 (9955185..9962995)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene PUL domain-containing protein;Ubiquitin fusion degradation protein 3 homolog Neighboring gene FAD synthase;Molybdenum cofactor biosynthesis protein-like region Neighboring gene Thymidylate kinase Neighboring gene ncRNA Neighboring gene Putative ATP synthase subunit f, mitochondrial

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Migrations of the Caenorhabditis elegans HSNs are regulated by egl-43, a gene encoding two zinc finger proteins. Garriga G, et al. Genes Dev, 1993 Nov. PMID 8224840
  2. Reevaluating the relationship between EGL-43 (EVI1) and LIN-12 (Notch) during C. elegans anchor cell invasion. Martinez MAQ, et al. Biol Open, 2022 Dec 15. PMID 36445013, Free PMC Article
  3. Cell interactions and patterned intercalations shape and link epithelial tubes in C. elegans. Rasmussen JP, et al. PLoS Genet, 2013. PMID 24039608, Free PMC Article
  4. Regulation of anchor cell invasion and uterine cell fates by the egl-43 Evi-1 proto-oncogene in Caenorhabditis elegans. Rimann I, et al. Dev Biol, 2007 Aug 1. PMID 17573066
  5. The Caenorhabditis elegans homolog of the Evi1 proto-oncogene, egl-43, coordinates G1 cell cycle arrest with pro-invasive gene expression during anchor cell invasion. Deng T, et al. PLoS Genet, 2020 Mar. PMID 32203506, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Reevaluating the relationship between EGL-43 (EVI1) and LIN-12 (Notch) during C. elegans anchor cell invasion.
    Title: Reevaluating the relationship between EGL-43 (EVI1) and LIN-12 (Notch) during C. elegans anchor cell invasion.
  2. MIG-10 stabilizes invading cell adhesion to basement membrane and is a negative transcriptional target of EGL-43 in C. elegans.
    Title: MIG-10 (Lamellipodin) stabilizes invading cell adhesion to basement membrane and is a negative transcriptional target of EGL-43 in C. elegans.
  3. EGL-43 is required to specify the cell fates of ventral uterus cells downstream of or in parallel with LIN-12 NOTCH.
    Title: Regulation of anchor cell invasion and uterine cell fates by the egl-43 Evi-1 proto-oncogene in Caenorhabditis elegans.
  4. egl-43 integrates temporally distinct upstream regulatory events and helps program cell fate specification and cell invasion
    Title: C. elegans EVI1 proto-oncogene, EGL-43, is necessary for Notch-mediated cell fate specification and regulates cell invasion.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Zinc finger protein egl-43
NP_001022288.1
  • Confirmed by transcript evidence
NP_001359539.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    9955185..9962995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027117.6 → NP_001022288.1  Zinc finger protein egl-43 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022288.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22023, Q22024, Q26336, Q26337, Q7JM79, Q7JPS6
    Conserved Domains (4) summary
    COG5189
    Location:115 → 210
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:446 → 466
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:444 → 466
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:458 → 482
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001373787.1 → NP_001359539.1  Zinc finger protein egl-43 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (3) summary
    sd00017
    Location:225 → 245
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:223 → 245
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:237 → 261
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_002363.2 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22024.1

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