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atf-2 Transcription factor atf-2 [ Caenorhabditis elegans ]

Gene ID: 174399, updated on 25-Apr-2024

Summary

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Gene symbol
atf-2
Gene description
Transcription factor atf-2
Primary source
WormBase:WBGene00000220
Locus tag
CELE_K08F8.2
See related
AllianceGenome:WB:WBGene00000220
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Is expressed in digestive tract; egg-laying apparatus; excretory system; neurons; and ventral nerve cord. Orthologous to human NFIL3 (nuclear factor, interleukin 3 regulated). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
6
Sequence:
Chromosome: II; NC_003280.10 (8751986..8753940)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene MARVEL domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The bZip proteins CES-2 and ATF-2 alter the timing of transcription for a cell-specific target gene in C. elegans. Wang X, et al. Dev Biol, 2006 Jan 15. PMID 16310763
  2. Isolation and characterization of pmk-(1-3): three p38 homologs in Caenorhabditis elegans. Berman K, et al. Mol Cell Biol Res Commun, 2001 Nov. PMID 11703092, Free PMC Article
  3. Discovery and characterization of a conserved pigment dispersing factor-like neuropeptide pathway in Caenorhabditis elegans. Janssen T, et al. J Neurochem, 2009 Oct. PMID 19686386
  4. Co-regulation by Notch and Fos is required for cell fate specification of intermediate precursors during C. elegans uterine development. Oommen KS, et al. Development, 2007 Nov. PMID 17942488
  5. Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans. Erdélyi P, et al. J Cell Sci, 2011 May 1. PMID 21502138, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We provide evidence that CES-2 and ATF-2 can interact with each other, and that they cooperate to form a complex on lin-48 regulatory sequences.
    Title: The bZip proteins CES-2 and ATF-2 alter the timing of transcription for a cell-specific target gene in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in circadian rhythm IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Transcription factor atf-2
NP_495861.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    8751986..8753940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063460.4 → NP_495861.1  Transcription factor atf-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495861.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21361
    Conserved Domains (2) summary
    cd14694
    Location:53 → 100
    bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain
    cd14695
    Location:328 → 386
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21361.1

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