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gtf-2F1 Transcription initiation factor IIF subunit alpha [ Caenorhabditis elegans ]

Gene ID: 173764, updated on 5-May-2024

Summary

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Gene symbol
gtf-2F1
Gene description
Transcription initiation factor IIF subunit alpha
Primary source
WormBase:WBGene00015296
Locus tag
CELE_C01F1.1
See related
AllianceGenome:WB:WBGene00015296
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA polymerase II general transcription initiation factor activity and TFIIF-class transcription factor complex binding activity. Predicted to be involved in transcription initiation from RNA polymerase II promoter. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIIF complex. Orthologous to human GTF2F1 (general transcription factor IIF subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (4301607..4305270)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene NAD(P)-bd_dom domain-containing protein;NAD(P)-binding domain-containing protein Neighboring gene Thioredoxin domain-containing protein Neighboring gene Thioredoxin domain-containing protein Neighboring gene UNC93-like protein MFSD11 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcription mechanisms. Blackwell TK, et al. WormBook, 2006 Sep 5. PMID 18050436, Free PMC Article
  2. FACT Sets a Barrier for Cell Fate Reprogramming in Caenorhabditis elegans and Human Cells. Kolundzic E, et al. Dev Cell, 2018 Sep 10. PMID 30078731, Free PMC Article
  3. The Regulatory Landscape of Lineage Differentiation in a Metazoan Embryo. Du Z, et al. Dev Cell, 2015 Sep 14. PMID 26321128, Free PMC Article
  4. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
  5. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables TFIIF-class transcription factor complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription elongation by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription initiation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription initiation at RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIF complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Transcription initiation factor IIF subunit alpha
NP_494756.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    4301607..4305270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062355.6 → NP_494756.1  Transcription initiation factor IIF subunit alpha [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494756.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17558
    Conserved Domains (2) summary
    cd00240
    Location:14 → 181
    TFIIFa; Transcription initiation factor IIF, alpha subunit, N-terminal region of RAP74. Subunit of transcription initiation complex involved in initiation, elongation and promoter escape.Tetramer of 2 alpha and 2 beta TFIIF subunits interacts directly with RNA ...
    pfam05793
    Location:2 → 474
    TFIIF_alpha; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
Nucleotide Protein
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