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sepa-1 Protein sepa-1 [ Caenorhabditis elegans ]

Gene ID: 173196, updated on 18-Sep-2024

Summary

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Official Symbol
sepa-1
Official Full Name
Protein sepa-1
Primary source
WormBase:WBGene00010808
Locus tag
CELE_M01E5.6
See related
AllianceGenome:WB:WBGene00010808
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein self-association and protein-macromolecule adaptor activity. Involved in autophagy. Located in cytoplasm. Is expressed in head; intestine; and tail. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003279.8 (13298204..13300716, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene tRNA-Lys Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene NTF2 domain-containing protein Neighboring gene SKN-1 Dependent Zygotic transcript

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Selective autophagic degradation of maternally-loaded germline P granule components in somatic cells during C. elegans embryogenesis. Zhao Y, et al. Autophagy, 2009 Jul. PMID 19372764
  2. Detecting Autophagy in Caenorhabditis elegans Embryos Using Markers of P Granule Degradation. Palmisano NJ, et al. Cold Spring Harb Protoc, 2016 Jan 4. PMID 26729906, Free PMC Article
  3. Hsp90-downregulation influences the heat-shock response, innate immune response and onset of oocyte development in nematodes. Eckl J, et al. PLoS One, 2017. PMID 29078207, Free PMC Article
  4. CUP-5, the C. elegans ortholog of the mammalian lysosomal channel protein MLN1/TRPML1, is required for proteolytic degradation in autolysosomes. Sun T, et al. Autophagy, 2011 Nov. PMID 21997367
  5. The composition of a protein aggregate modulates the specificity and efficiency of its autophagic degradation. Zhang G, et al. Autophagy, 2017 Sep 2. PMID 28806108, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-macromolecule adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein sepa-1
NP_493339.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    13298204..13300716 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060938.4 → NP_493339.1  Protein sepa-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493339.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EC37
    Conserved Domains (1) summary
    pfam02172
    Location:600 → 676
    KIX; KIX domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EC37.1

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