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aph-2 Nicastrin [ Caenorhabditis elegans ]

Gene ID: 172905, updated on 18-Sep-2024

Summary

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Official Symbol
aph-2
Official Full Name
Nicastrin
Primary source
WormBase:WBGene00000148
Locus tag
CELE_ZC434.6
See related
AllianceGenome:WB:WBGene00000148
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in several processes, including Notch signaling pathway; oviposition; and pharynx development. Located in plasma membrane. Is expressed in oocyte. Human ortholog(s) of this gene implicated in Alzheimer's disease; hidradenitis suppurativa; and schizophrenia. Orthologous to human NCSTN (nicastrin). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: I
Exon count:
8
Sequence:
Chromosome: I; NC_003279.8 (10340997..10345654)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene DUF3421 domain-containing protein Neighboring gene DUF3421 domain-containing protein Neighboring gene glutamate--tRNA ligase Neighboring gene Cytochrome c oxidase assembly factor 6 homolog;PRORP domain-containing protein Neighboring gene putative arginine kinase ZC434.8 Neighboring gene ShKT domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. APH-2/nicastrin functions in LIN-12/Notch signaling in the Caenorhabditis elegans somatic gonad. Levitan D, et al. Dev Biol, 2001 Dec 15. PMID 11784090
  2. aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling. Goutte C, et al. Development, 2000 Jun. PMID 10804188
  3. MEX-3 is a KH domain protein that regulates blastomere identity in early C. elegans embryos. Draper BW, et al. Cell, 1996 Oct 18. PMID 8861905
  4. Genetics leads the way to the accomplices of presenilins. Goutte C. Dev Cell, 2002 Jul. PMID 12110162
  5. Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Yu G, et al. Nature, 2000 Sep 7. PMID 10993067

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Notch signaling without the APH-2/nicastrin subunit of gamma secretase in Caenorhabditis elegans germline stem cells.
    Title: Notch signaling without the APH-2/nicastrin subunit of gamma secretase in Caenorhabditis elegans germline stem cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in Notch receptor processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell fate commitment involved in pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pharynx development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of gamma-secretase complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nicastrin
NP_001122563.1
  • Confirmed by transcript evidence
NP_492712.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    10340997..10345654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060311.4 → NP_492712.2  Nicastrin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492712.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23316
    Conserved Domains (1) summary
    cd03881
    Location:171 → 500
    M28_Nicastrin; M28 Zn-Peptidase Nicastrin, a main component of gamma-secretase complex

  2. NM_001129091.3 → NP_001122563.1  Nicastrin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122563.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A5Z2T7
    Conserved Domains (1) summary
    cd03881
    Location:37 → 665
    M28_Nicastrin; M28 Zn-peptidase nicastrin, a main component of gamma-secretase complex
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q23316.3

Gene LinkOut

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