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gon-2 LSDAT_euk domain-containing protein;Transient receptor potential channel [ Caenorhabditis elegans ]

Gene ID: 172646, updated on 23-May-2024

Summary

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Gene symbol
gon-2
Gene description
LSDAT_euk domain-containing protein;Transient receptor potential channel
Primary source
WormBase:WBGene00001651
Locus tag
CELE_T01H8.5
See related
AllianceGenome:WB:WBGene00001651
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cation channel activity. Involved in defecation; gonad development; and mitotic cell cycle. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in excretory cell; gonad; intestine; pharynx; and rectal epithelium. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1; congenital stationary night blindness; congenital stationary night blindness 1C; intestinal hypomagnesemia 1; and metal metabolism disorder. Orthologous to several human genes including TRPM3 (transient receptor potential cation channel subfamily M member 3) and TRPM7 (transient receptor potential cation channel subfamily M member 7). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See gon-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
30
Sequence:
Chromosome: I; NC_003279.8 (8549519..8570998, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Transmembrane protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene L-serine ammonia-lyase Neighboring gene Putative ribosomal protein S6 kinase alpha-1;Ribosomal protein S6 kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The C. elegans gon-2 gene encodes a putative TRP cation channel protein required for mitotic cell cycle progression. West RJ, et al. Gene, 2001 Mar 21. PMID 11290424
  2. Gem-1 encodes an SLC16 monocarboxylate transporter-related protein that functions in parallel to the gon-2 TRPM channel during gonad development in Caenorhabditis elegans. Kemp BJ, et al. Genetics, 2009 Feb. PMID 19087963, Free PMC Article
  3. Highly Ca2+-selective TRPM channels regulate IP3-dependent oscillatory Ca2+ signaling in the C. elegans intestine. Xing J, et al. J Gen Physiol, 2008 Mar. PMID 18299395, Free PMC Article
  4. TRPM channel function in Caenorhabditis elegans. Baylis HA, et al. Biochem Soc Trans, 2007 Feb. PMID 17233618
  5. Diethylcarbamazine activates TRP channels including TRP-2 in filaria, Brugia malayi. Verma S, et al. Commun Biol, 2020 Jul 28. PMID 32724078, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the activity of GTL-2 balances the activities of the paralogous TRPM channel proteins, GON-2 and GTL-1
    Title: Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel.
  2. PIP(2)-dependent regulation of GON-2/GTL-1 may provide a mechanism to coordinate plasma membrane Ca(2+) influx with PLCgamma and IP(3) receptor activity as well as intracellular Ca(2+) store depletion.
    Title: Phosphatidylinositol 4,5-bisphosphate and loss of PLCgamma activity inhibit TRPM channels required for oscillatory Ca2+ signaling.
  3. Inactivation of gem-1 enhances the gonadogenesis defects of gon-2 hypomorphic mutations, suggesting that these two genes probably act in parallel to promote gonadal cell divisions.
    Title: Gem-1 encodes an SLC16 monocarboxylate transporter-related protein that functions in parallel to the gon-2 TRPM channel during gonad development in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables monoatomic cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoatomic cation transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in defecation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in defecation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in metal ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic cation transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic cation transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
LSDAT_euk domain-containing protein;Transient receptor potential channel
NP_001122505.1
  • Confirmed by transcript evidence
NP_001122506.1
  • Confirmed by transcript evidence
NP_001129788.1
  • Confirmed by transcript evidence
NP_001359707.1
  • Confirmed by transcript evidence
NP_492315.4
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    8549519..8570998 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059914.8 → NP_492315.4  Transient receptor potential channel [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492315.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P91909, Q93971
    UniProtKB/TrEMBL
    Q8IG04
    Conserved Domains (2) summary
    pfam00520
    Location:1328 → 1567
    Ion_trans; Ion transport protein
    pfam07695
    Location:1299 → 1462
    7TMR-DISM_7TM; 7TM diverse intracellular signalling

  2. NM_001373178.2 → NP_001359707.1  LSDAT_euk domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EE91, Q8IG04
    Conserved Domains (2) summary
    pfam00520
    Location:1207 → 1466
    Ion_trans; Ion transport protein
    pfam18139
    Location:291 → 555
    LSDAT_euk; SLOG in TRPM

  3. NM_001129034.3 → NP_001122506.1  LSDAT_euk domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122506.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EGP7, Q8IG04
    Conserved Domains (2) summary
    pfam00520
    Location:1267 → 1506
    Ion_trans; Ion transport protein
    pfam07695
    Location:1238 → 1401
    7TMR-DISM_7TM; 7TM diverse intracellular signalling

  4. NM_001136316.4 → NP_001129788.1  LSDAT_euk domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129788.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EGJ6, Q8IG04
    Conserved Domains (1) summary
    pfam00520
    Location:922 → 1161
    Ion_trans; Ion transport protein

  5. NM_001129033.3 → NP_001122505.1  Transient receptor potential channel [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122505.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A5JYU8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q93971.4

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