ath-1 palmitoyl-protein hydrolase [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: ath-1
Gene description: palmitoyl-protein hydrolase
Primary source: WormBase:WBGene00010564
Locus tag: CELE_K04G2.5
See related: AllianceGenome:WB:WBGene00010564
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable carboxylic ester hydrolase activity and palmitoyl-(protein) hydrolase activity. Predicted to be involved in protein depalmitoylation. Predicted to be active in cytoplasm. Orthologous to human LYPLA1 (lysophospholipase 1) and LYPLA2 (lysophospholipase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: I

Exon count:: 7

Sequence:: Chromosome: I; NC_003279.8 (8036941..8039752, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K04G2.5 (e-PCR)
- UniSTS:319487

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables carboxylic ester hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables palmitoyl-(protein) hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in macromolecule depalmitoylation	IEA Inferred from Electronic Annotation more info
involved_in protein depalmitoylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: palmitoyl-protein hydrolase

NP_001293296.1

Confirmed by transcript evidence

NP_001379150.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

8036941..8039752 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392635.1 → NP_001379150.1 palmitoyl-protein hydrolase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5ED25, Q21224

Conserved Domains (1) summary

pfam02230
Location:6 → 221

Abhydrolase_2; Phospholipase/Carboxylesterase
NM_001306367.3 → NP_001293296.1 palmitoyl-protein hydrolase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293296.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A061ACY0

Conserved Domains (1) summary

pfam02230
Location:87 → 302

Abhydrolase_2; Phospholipase/Carboxylesterase