U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

bli-4 Endoprotease bli-4 [ Caenorhabditis elegans ]

Gene ID: 172333, updated on 25-Apr-2024

Summary

Go to the top of the page Help
Gene symbol
bli-4
Gene description
Endoprotease bli-4
Primary source
WormBase:WBGene00000254
Locus tag
CELE_K04F10.4
See related
AllianceGenome:WB:WBGene00000254
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable serine-type endopeptidase activity. Involved in several processes, including cellular response to salt; collagen and cuticulin-based cuticle development; and positive regulation of synaptic assembly at neuromuscular junction. Located in nucleus. Is expressed in head; hypodermis; intestine; reproductive system; and ventral cord neurons. Orthologous to human PCSK5 (proprotein convertase subtilisin/kexin type 5) and PCSK6 (proprotein convertase subtilisin/kexin type 6). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: I
Exon count:
26
Sequence:
Chromosome: I; NC_003279.8 (6342224..6356680)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene MS Related Protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene PAP-associated domain-containing protein;Polymerase nucleotidyl transferase domain-containing protein Neighboring gene Vacuolar protein sorting-associated protein 28 homolog Neighboring gene Protein KATNIP homolog

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cloning and biochemical characterization of blisterase, a subtilisin-like convertase from the filarial parasite, Onchocerca volvulus. Poole CB, et al. J Biol Chem, 2003 Sep 19. PMID 12855702
  2. WABA success: a tool for sequence comparison between large genomes. Baillie DL, et al. Genome Res, 2000 Aug. PMID 10958624
  3. Mutational analysis of bli-4/kpc-4 reveals critical residues required for proprotein convertase function in C. elegans. Thacker C, et al. Gene, 2000 Jul 11. PMID 10903434
  4. Functional genomics in Caenorhabditis elegans: An approach involving comparisons of sequences from related nematodes. Thacker C, et al. Genome Res, 1999 Apr. PMID 10207157, Free PMC Article
  5. The bli-4 locus of Caenorhabditis elegans encodes structurally distinct kex2/subtilisin-like endoproteases essential for early development and adult morphology. Thacker C, et al. Genes Dev, 1995 Apr 15. PMID 7774813

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The proprotein convertase BLI-4 promotes collagen secretion prior to assembly of the Caenorhabditis elegans cuticle.
    Title: The proprotein convertase BLI-4 promotes collagen secretion prior to assembly of the Caenorhabditis elegans cuticle.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to salt IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to salt IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemosensory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in collagen and cuticulin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of synaptic assembly at neuromuscular junction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Endoprotease bli-4
NP_001021540.1
  • Confirmed by transcript evidence
NP_001021543.1
  • Confirmed by transcript evidence
NP_001303778.1
  • Confirmed by transcript evidence
NP_001303779.1
  • Confirmed by transcript evidence
NP_001303781.1
  • Confirmed by transcript evidence
NP_001360008.1
  • Confirmed by transcript evidence
NP_001367785.1
  • Confirmed by transcript evidence
NP_001367786.1
  • Partially confirmed by transcript evidence
NP_001367787.1
  • Confirmed by transcript evidence
NP_001368583.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6342224..6356680
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001372959.2 → NP_001360008.1  Endoprotease bli-4 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (3) summary
    cd04059
    Location:160 → 448
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    pfam01483
    Location:536 → 623
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:43 → 116
    S8_pro-domain; Peptidase S8 pro-domain

  2. NM_001026372.7 → NP_001021543.1  Endoprotease bli-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021543.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0M7RDN9, A0A0M7RDU4, A0A0M7RE83, A0A0M7RFE9, G8JYA5, O44762, O44763, O44764, O44765, O44766, P51559
    Conserved Domains (6) summary
    cd04059
    Location:160 → 448
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:804 → 847
    FU; Furin-like repeats
    cd00064
    Location:675 → 728
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam01483
    Location:536 → 623
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:43 → 116
    S8_pro-domain; Peptidase S8 pro-domain
    cl28643
    Location:716 → 856
    VSP; Giardia variant-specific surface protein

  3. NM_001316849.3 → NP_001303778.1  Endoprotease bli-4 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P51559
    Conserved Domains (4) summary
    cd04059
    Location:160 → 448
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    pfam00082
    Location:193 → 465
    Peptidase_S8; Subtilase family
    pfam01483
    Location:536 → 623
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:43 → 116
    S8_pro-domain; Peptidase S8 pro-domain

  4. NM_001316852.3 → NP_001303781.1  Endoprotease bli-4 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P51559
    Conserved Domains (4) summary
    cd04059
    Location:160 → 448
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    pfam00082
    Location:193 → 465
    Peptidase_S8; Subtilase family
    pfam01483
    Location:536 → 623
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:43 → 116
    S8_pro-domain; Peptidase S8 pro-domain

  5. NM_001316850.3 → NP_001303779.1  Endoprotease bli-4 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P51559
    Conserved Domains (4) summary
    cd04059
    Location:160 → 448
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    pfam00082
    Location:193 → 465
    Peptidase_S8; Subtilase family
    pfam01483
    Location:536 → 623
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:43 → 116
    S8_pro-domain; Peptidase S8 pro-domain

  6. NM_001026369.7 → NP_001021540.1  Endoprotease bli-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021540.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P51559
    Conserved Domains (4) summary
    cd04059
    Location:160 → 448
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    pfam00082
    Location:193 → 465
    Peptidase_S8; Subtilase family
    pfam01483
    Location:536 → 623
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:43 → 116
    S8_pro-domain; Peptidase S8 pro-domain

  7. NM_001380517.2 → NP_001367786.1  Endoprotease bli-4 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (5) summary
    cd04059
    Location:160 → 448
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:724 → 773
    FU; Furin-like repeats
    cd00064
    Location:675 → 728
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam01483
    Location:536 → 623
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:43 → 116
    S8_pro-domain; Peptidase S8 pro-domain

  8. NM_001380518.3 → NP_001367785.1  Endoprotease bli-4 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (3) summary
    cd04059
    Location:160 → 448
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    pfam01483
    Location:536 → 623
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:43 → 116
    S8_pro-domain; Peptidase S8 pro-domain

  9. NM_001380521.1 → NP_001368583.1  Endoprotease bli-4 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (3) summary
    cd04059
    Location:160 → 448
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    pfam01483
    Location:536 → 623
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:43 → 116
    S8_pro-domain; Peptidase S8 pro-domain

  10. NM_001380523.1 → NP_001367787.1  Endoprotease bli-4 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (3) summary
    cd04059
    Location:160 → 448
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    pfam01483
    Location:536 → 623
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:43 → 116
    S8_pro-domain; Peptidase S8 pro-domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51559.3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous