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pgk-1 putative phosphoglycerate kinase [ Caenorhabditis elegans ]

Gene ID: 171965, updated on 18-Sep-2024

Summary

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Official Symbol
pgk-1
Official Full Name
putative phosphoglycerate kinase
Primary source
WormBase:WBGene00020185
Locus tag
CELE_T03F1.3
See related
AllianceGenome:WB:WBGene00020185
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ADP binding activity; ATP binding activity; and phosphoglycerate kinase activity. Predicted to be involved in gluconeogenesis and glycolytic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in hemolytic anemia and phosphoglycerate kinase 1 deficiency. Orthologous to several human genes including PGK1 (phosphoglycerate kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (3867541..3869109)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene guanylate kinase Neighboring gene HoloCentric chromosome binding Protein Neighboring gene Ubiquinone biosynthesis protein coq-4, mitochondrial Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Glyceraldehyde-3-phosphate dehydrogenase mediates anoxia response and survival in Caenorhabditis elegans. Mendenhall AR, et al. Genetics, 2006 Nov. PMID 16980394, Free PMC Article
  2. Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans. McElwee JJ, et al. Mech Ageing Dev, 2006 May. PMID 16522328
  3. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813
  4. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
  5. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ADP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoglycerate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoglycerate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoglycerate kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative phosphoglycerate kinase
NP_491245.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3867541..3869109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058844.8 → NP_491245.1  putative phosphoglycerate kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491245.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P91427
    Conserved Domains (1) summary
    PTZ00005
    Location:5 → 414
    PTZ00005; phosphoglycerate kinase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P91427.1

Gene LinkOut

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