Slc26a6 solute carrier family 26, member 6 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Slc26a6provided by MGI
Official Full Name: solute carrier family 26, member 6provided by MGI
Primary source: MGI:2159728
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CFEX; Pat1; B930010B04Rik
Annotation information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly

Genomic context

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Location :: 9 F2; 9

Sequence :: Chromosome: 9; NC_000075.6 (108854043..108862143); Chromosome: 9; NC_000075.6 (108912410..108913049)

See Slc26a6 in Epigenomics, MapViewer

Chromosome 9 - NC_000075.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

NMR and CE were used to characterize the urinary metabolome in slc26a6 null mice. Clear metabolic differentiation between the urinary profiles of the slc26a6 null and the wild type mice were observed using both methods.
Title: Urinary metabolic phenotyping the slc26a6 (chloride-oxalate exchanger) null mouse model.
SLC26A6 mediates 1:2 Cl-/HCO3- exchange, and the exchanger most probably upregulates SLC26A3 in its absence, therefore mediating 2:1 exchange.
Title: Deletion of Slc26a6 alters the stoichiometry of apical Cl-/HCO-3 exchange in mouse pancreatic duct.
Data demonstrate functional Pat-1 Cl)/HCO3) exchange activity in the lower villus epithelium of the murine duodenum which, in previous studies, had been obscured by the inclusion of luminal glucose as a metabolic substrate.
Title: Functional activity of Pat-1 (Slc26a6) Cl(−)/HCO₃(−) exchange in the lower villus epithelium of murine duodenum.
This study showed a functionally active CFTR is an absolute requirement for Slc26-mediated duodenal bicarbonate secretion, but not for Slc26-mediated fluid absorption.
Title: The switch of intestinal Slc26 exchangers from anion absorptive to HCOFormula secretory mode is dependent on CFTR anion channel function.
study concludes Pat-1 Cl(-)/HCO(3)(-) exchange contributes to pH(i) regulation in the duodenal villous epithelium during H(+)-dipeptide absorption, possibly by providing a HCO(3)(-) import pathway
Title: Putative anion transporter-1 (Pat-1, Slc26a6) contributes to intracellular pH regulation during H+-dipeptide transport in duodenal villous epithelium.
Suggest that Slc26a6A is the most likely candidate for the major apical SO(4)(2-) transporter that mediates SO(4)(2-) secretion in the kidney of marine teleosts.
Title: Identification of renal transporters involved in sulfate excretion in marine teleost fish.
Data strongly suggest that Slc26a6 acts in concert with NHE3 in electroneutral salt absorption in the small intestine.
Title: Sodium and chloride absorptive defects in the small intestine in Slc26a6 null mice.
Low extracellular Cl(-) affinity and electroneutrality of oxalate efflux characterizing human SLC26A6 explain the high human susceptibility to nephrolithiasis relative to mice. SLC26A6 sequence variant(s) are candidate risk modifiers for nephrolithiasis.
Title: Species differences in Cl- affinity and in electrogenicity of SLC26A6-mediated oxalate/Cl- exchange correlate with the distinct human and mouse susceptibilities to nephrolithiasis.
Slc26a6 (PAT1) deletion downregulates the apical Na+/H+ exchanger in the straight segment of the proximal tubule
Title: Slc26a6 (PAT1) deletion downregulates the apical Na+/H+ exchanger in the straight segment of the proximal tubule.
We conclude that PAT1 is DIDS sensitive and mediates a significant fraction of oxalate efflux across the apical membrane in exchange for Cl(-).
Title: Ileal oxalate absorption and urinary oxalate excretion are enhanced in Slc26a6 null mice.

Submit: New GeneRIF Correction See all (23)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (3) 1 citation

Pathways from BioSystems

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Mineral absorption, organism-specific biosystem (from KEGG)
Mineral absorption, organism-specific biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
Mineral absorption, conserved biosystem (from KEGG)
Mineral absorption, conserved biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
Multifunctional anion exchangers, organism-specific biosystem (from REACTOME)
Multifunctional anion exchangers, organism-specific biosystemcomputationally inferred pathway (not manually curated)
SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
SLC-mediated transmembrane transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
Transmembrane transport of small molecules, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transport of inorganic cations/anions and amino acids/oligopeptides, organism-specific biosystem (from REACTOME)
Transport of inorganic cations/anions and amino acids/oligopeptides, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Homology

Homologs of the Slc26a6 gene: The Slc26a6 gene is conserved in human, chimpanzee, dog, cow, rat, chicken, zebrafish, mosquito, C.elegans, A.thaliana, and rice.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
anion:anion antiporter activity	IDA Inferred from Direct Assay more info	PubMed
chloride transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
formate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
bicarbonate transport	IDA Inferred from Direct Assay more info	PubMed
bicarbonate transport	IMP Inferred from Mutant Phenotype more info	PubMed
chloride transport	IDA Inferred from Direct Assay more info	PubMed
formate transport	IDA Inferred from Direct Assay more info	PubMed
ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
transmembrane transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
integral to membrane	IEA Inferred from Electronic Annotation more info
integral to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: solute carrier family 26, member 6

Names: solute carrier family 26, member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134420.4 → NP_599252.2 solute carrier family 26, member 6

Status: VALIDATED

Source sequence(s)

AF248494, AK029238, AK163671

UniProtKB/TrEMBL

Q3TQD3

UniProtKB/TrEMBL

Q8CJD0

UniProtKB/TrEMBL

Q8K142

Conserved Domains (4) summary

cd07042
Location:634 – 711
Blast Score: 141

STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function

pfam00916
Location:186 – 454
Blast Score: 488

Sulfate_transp; Sulfate transporter family

pfam13792
Location:54 – 136
Blast Score: 255

Sulfate_tra_GLY; Sulfate transporter N-terminal domain with GLY motif

cl00604
Location:509 – 546
Blast Score: 87

STAS; Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000075.6 Reference GRCm38.p1 C57BL/6J

Range

108854043..108862143

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000031.1 Alternate Mm_Celera

Range

108461213..108471055

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01081575.1	None
genomic	AAHY01081576.1	None
genomic	AC168054.4 (132215..136974)	None
genomic	CAAA01111125.1	None
genomic	CAAA01200220.1 (6726..7365)	None
genomic	CH466560.1	EDL21318.1	mixed
		EDL21319.1	mixed
		EDL21320.1	mixed
		EDL21321.1	mixed
		EDL21322.1	mixed
mRNA	AB099881.1	BAC55182.1	BALB/c
mRNA	AF248494.1	AAN07089.1
mRNA	AK029238.1	None	C57BL/6J
mRNA	AK046993.1	None	C57BL/6J
mRNA	AK053088.1	None	C57BL/6J
mRNA	AK080750.1	None	C57BL/6J
mRNA	AK163670.1	BAE37450.1	C57BL/6J
mRNA	AK163671.1	BAE37451.1	C57BL/6J
mRNA	AY032863.1	AAK51131.1	BALB/c
mRNA	AY049076.1	AAL13129.1	C57BL/6J
mRNA	BC028856.1	AAH28856.1	FVB/N
mRNA	BM950449.1	None	C57BL/6
mRNA	CN692543.1	None	C57BL/6J