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    TICAM1 toll-like receptor adaptor molecule 1 [ Homo sapiens ]

    Gene ID: 148022, updated on 19-May-2012
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    Summary

    Official Symbol
    TICAM1provided by HGNC
    Official Full Name
    toll-like receptor adaptor molecule 1provided by HGNC
    Primary source
    HGNC:18348
    See related
    Ensembl:ENSG00000127666; HPRD:06350; MIM:607601
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRIF; PRVTIRB; TICAM-1; MGC35334
    Summary
    This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012]
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    Genomic context

    Location :
    19p13.3
    Sequence :
    Chromosome: 19; NC_000019.9 (4815938..4831737, complement)
    See TICAM1 in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100507004 Neighboring gene fem-1 homolog a (C. elegans) Neighboring gene perilipin 3 Neighboring gene arrestin domain containing 5

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. [The activation of TRIF-dependent signaling pathway in THP-1 cells induced by β₂ GPI/anti-β₂ GPI antibodies complex]. Xie HX, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2011 Dec. PMID 22152804.
    2. Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency. Sancho-Shimizu V, et al. J Clin Invest, 2011 Dec. PMID 22105173.
    3. The proteoglycan biglycan enhances antigen-specific T cell activation potentially via MyD88 and TRIF pathways and triggers autoimmune perimyocarditis. Popovic ZV, et al. J Immunol, 2011 Dec 15. PMID 22095710.
    4. CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines. Kim EJ, et al. Immunology, 2012 Mar. PMID 22043923.
    5. The TLR3/TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection. Oshiumi H, et al. J Immunol, 2011 Nov 15. PMID 21998457.

    See all (75) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. TRIF may play an important role in the pathogenesis of antiphospholipid syndrome.
      Title: [The activation of TRIF-dependent signaling pathway in THP-1 cells induced by β₂ GPI/anti-β₂ GPI antibodies complex].
    2. regulation of the TLR3/TRIF-mediated pathway required the combined action of SHP-1 and SHP-2, which could be accomplished by CD300f but not CD300a
      Title: CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines.
    3. The TLR2/4 ligand biglycan enhances antigen-specific T cell priming via MyD88 and Toll-like receptor adapter molecule TRIF pathways, triggering autoimmune perimyocarditis in transgenic mice.
      Title: The proteoglycan biglycan enhances antigen-specific T cell activation potentially via MyD88 and TRIF pathways and triggers autoimmune perimyocarditis.
    4. Hepatitis A virus inhibits TLR3 signaling by reducing abundance of the adaptor protein TRIF.
      Title: Disruption of TLR3 signaling due to cleavage of TRIF by the hepatitis A virus protease-polymerase processing intermediate, 3CD.
    5. Susceptibility to herpes simplex encephalitis is caused by TRIF nonsense (autosomal recessive) TRIF deficiency or a missense mutation (autosomal dominant). TRIf is needed for TLR3-dependent interferon synthesis.
      Title: Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency.
    6. The host TICAM-1 transgene pathway is essential for antiviral responses that suppress poliovirus infection, which is exacerbated in TICAM-1-deficient poliovirus receptor-bearing mice.
      Title: The TLR3/TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection.
    7. show that hBD3 reduces NF-kappaB signaling in cells transfected with MyD88 or TRIF
      Title: Human β-defensin 3 affects the activity of pro-inflammatory pathways associated with MyD88 and TRIF.
    8. These studies establish that MyD88 but not Trif signaling plays a critical role in mediating cardiac dysfunction, systemic inflammation, and mortality during polymicrobial sepsis
      Title: MyD88 and Trif signaling play distinct roles in cardiac dysfunction and mortality during endotoxin shock and polymicrobial sepsis.
    9. PLIC-1 is a novel inhibitor of the TLR3-Trif antiviral pathway by reducing the abundance of Trif
      Title: The ubiquitin-like protein PLIC-1 or ubiquilin 1 inhibits TLR3-Trif signaling.
    10. TRIF cleavage mediated by human enterovirus 71 3C protease may be a mechanism to impair type I interferon production in response to Toll-like receptor 3 (TLR3) activation.
      Title: Cleavage of the adaptor protein TRIF by enterovirus 71 3C inhibits antiviral responses mediated by Toll-like receptor 3.
    Submit: New GeneRIF Correction See all (43)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_891549.1 NP_037386.1 TBK1    BIND  PubMed TRIF interacts with TBK1. 
    NP_891549.1 NP_004611.1 TRAF6    BIND  PubMed TRIF interacts with TRAF6. 
    Toll-like receptor adaptor molecule 1 Q9H6S1 AZI2    HPRD  PubMed  
    Toll-like receptor adaptor molecule 1 Q14164 IKBKE    HPRD  PubMed  
    Toll-like receptor adaptor molecule 1 Q14653 IRF3    HPRD  PubMed  
    Toll-like receptor adaptor molecule 1 Q92985 IRF7    HPRD  PubMed  
    Toll-like receptor adaptor molecule 1 KIAA1271 protein MAVS    HPRD  PubMed  
    Toll-like receptor adaptor molecule 1 Q8N2W9 PIAS4    HPRD  PubMed  
    Toll-like receptor adaptor molecule 1 P42336 PIK3CA    HPRD  PubMed  
    Toll-like receptor adaptor molecule 1 Q13546 RIPK1    HPRD  PubMed  
    Toll-like receptor adaptor molecule 1 Q9Y572 RIPK3    HPRD  PubMed  
    Toll-like receptor adaptor molecule 1 Q9UHD2 TBK1    HPRD  PubMed  
    Toll-like receptor adaptor molecule 1 Toll like receptor adaptor molecule 2 TICAM2    HPRD  PubMed  
    Toll-like receptor adaptor molecule 1 P58753 TIRAP    HPRD  PubMed  
    Toll-like receptor adaptor molecule 1 O60603 TLR2    HPRD  PubMed  
    Toll-like receptor adaptor molecule 1 O15455 TLR3    HPRD  PubMed  
    Toll-like receptor adaptor molecule 1 P21580 TNFAIP3    HPRD  PubMed  
    Toll-like receptor adaptor molecule 1 Q13077 TRAF1    HPRD  PubMed  
    Toll-like receptor adaptor molecule 1 Q13114 TRAF3    HPRD  PubMed  
    Toll-like receptor adaptor molecule 1 Q9BUZ4 TRAF4    HPRD  PubMed  
    Toll-like receptor adaptor molecule 1 Q9Y4K3 TRAF6    HPRD  PubMed  
    Toll-like receptor adaptor molecule 1 Q15629 TRAM1    HPRD  PubMed  
    BioGRID:127114 BioGRID:114274 RIPK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:127114 BioGRID:116224 RIPK3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:127114 BioGRID:119981 RNF216    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:127114 BioGRID:115328 TANK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:127114 BioGRID:118878 TBK1    BioGRID  PubMed Affinity Capture-MS 
    NP_067681.1 TICAM2    BIND  PubMed TIRP interacts with TRIF. 
    NP_006281.1 TNFAIP3    BIND  PubMed An unspecified isoform of TRIF interacts with A20. This interaction was modeled on a demonstrated interaction between TRIF from an unspecified species and A20 from an unspecified species. 
    BioGRID:127114 BioGRID:113038 TRAF2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Two-hybrid 
    NP_004611.1 TRAF6    BIND  PubMed An unspecified isoform of TRIF interacts with TRAF6. This interaction was modeled on a demonstrated interaction between TRIF from an unspecified species and TRAF from an unspecified species. 
    BioGRID:127114 BioGRID:113041 TRAF6    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:127114 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
      Activated TLR4 signalling, organism-specific biosystemTLR4 is unique among the TLR family in its ability to recruit four adapters to activate two distinct signaling pathways. One pathway is activated by the pair of the adapters Mal or TIRAP (Toll/inter...
    • Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, organism-specific biosystem (from REACTOME)
      Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, organism-specific biosystemCell stimulation with viral ds RNA leads to the activation of two IKK-related serine/threonine kinases, TBK1 and IKK-i which directly phosphorylate IRF3 and IRF7 promoting their dimerization and tran...
    • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Cytosolic sensors of pathogen-associated DNA, organism-specific biosystem (from REACTOME)
      Cytosolic sensors of pathogen-associated DNA, organism-specific biosystemPresence of pathogen-associated DNA in cytosol induces type I IFN production. Several intracellular receptors have been implicated to some degree. These include DNA-dependent activator of interferon ...
    • DAI mediated induction of type I IFNs, organism-specific biosystem (from REACTOME)
      DAI mediated induction of type I IFNs, organism-specific biosystemDNA-dependent activator of IFN-regulatory factors (DAI), also known as Z-DNA-binding protein-1 (ZBP-1), was reported to initiate innate immune responses in murine L929 cells upon stimulation by multi...
    • Hepatitis C, organism-specific biosystem (from KEGG)
      Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Hepatitis C, conserved biosystem (from KEGG)
      Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • IKK complex recruitment mediated by RIP1, organism-specific biosystem (from REACTOME)
      IKK complex recruitment mediated by RIP1, organism-specific biosystemReceptor-interacting protein 1 (RIP1) mediates the activation of proinflammatory cytokines via intermediate induction of IKK complex in NFkB pathways (Ea et al. 2006). RIP1 was shown to be dispensabl...
    • IRAK2 mediated activation of TAK1 complex, organism-specific biosystem (from REACTOME)
      IRAK2 mediated activation of TAK1 complex, organism-specific biosystemAlthough IRAK-1 was originally thought to be a key mediator of TRAF6 activation in the IL1R/TLR signaling (Dong W et al. 2006), recent studies showed that IRAK-2, but not IRAK-1, led to TRAF6 polyubi...
    • IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, organism-specific biosystem (from REACTOME)
      IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, organism-specific biosystemAlthough IRAK-1 was originally thought to be a key mediator of TRAF6 activation in the IL1R/TLR signaling (Dong W et al. 2006), recent studies showed that IRAK-2, but not IRAK-1, led to TRAF6 polyubi...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • MyD88 cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
      MyD88 cascade initiated on plasma membrane, organism-specific biosystemMammalian myeloid differentiation factor 88 (MyD88) is Toll/interleukin (IL)-1 (TIR)-domain containing adapter protein which plays crucial role in TLR signaling. All TLRs, with only one exception of...
    • MyD88 dependent cascade initiated on endosome, organism-specific biosystem (from REACTOME)
      MyD88 dependent cascade initiated on endosome, organism-specific biosystemUpon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I ...
    • MyD88-independent cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
      MyD88-independent cascade initiated on plasma membrane, organism-specific biosystemThe MyD88-independent signaling route utilizes TRAM and TRIF adapters, that are essential for production of both type 1 interferons(IFNs) and pro-inflammatory cytokines. TRAM is thought to bridge bet...
    • MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
      MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystemThe first known downstream component of TLR4 and TLR2 signaling is the adaptor MyD88. Another adapter MyD88-adaptor-like (Mal; also known as TIR-domain-containing adaptor protein or TIRAP) has also b...
    • NFkB and MAP kinases activation mediated by TLR4 signaling repertoire, organism-specific biosystem (from REACTOME)
      NFkB and MAP kinases activation mediated by TLR4 signaling repertoire, organism-specific biosystemMitogen activated protein kinase (MAPK) cascade, one of the most ancient and evolutionarily conserved signaling pathways, is involved in many processes of immune responses. The MAP kinases cascade tr...
    • Pertussis, organism-specific biosystem (from KEGG)
      Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Pertussis, conserved biosystem (from KEGG)
      Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • RIP-mediated NFkB activation via DAI, organism-specific biosystem (from REACTOME)
      RIP-mediated NFkB activation via DAI, organism-specific biosystemOverexpression of human or murine DAI in human embryonic kidney 293T cells (HEK293T) activated NF-kB-dependent promoter in a dose-dependent manner. Two RHIM-contaning kinases RIP1 and RIP3 are implic...
    • TRAF6 Mediated Induction of proinflammatory cytokines, organism-specific biosystem (from REACTOME)
      TRAF6 Mediated Induction of proinflammatory cytokines, organism-specific biosystemIn human, together with ubiquitin-conjugating E2-type enzymes UBC13 and UEV1A (also known as UBE2V1), TRAF6 catalyses Lys63-linked ubiquitination. It is believed that auto polyubiquitination and oli...
    • TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystem (from REACTOME)
      TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystemTRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.
    • TRAF6 mediated induction of TAK1 complex, organism-specific biosystem (from REACTOME)
      TRAF6 mediated induction of TAK1 complex, organism-specific biosystemIn human, together with ubiquitin-conjugating E2-type enzymes UBC13 and UEV1A (also known as UBE2V1), TRAF6 catalyses Lys63-linked ubiquitination. It is believed that auto polyubiquitination and oli...
    • TRIF mediated TLR3 signaling, organism-specific biosystem (from REACTOME)
      TRIF mediated TLR3 signaling, organism-specific biosystemTIR-domain-containing adaptor inducing interferon-beta (TRIF or TIKAM1) is known to be an essential and exclusive adaptor used by TLR3; all the poly(I:C)-induced pathways leading to NFkB and IRF3 act...
    • Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemLittle is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may als...
    • Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemTLR2 is involved in recognition of peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprotein and mycobacterial products. It is quite possible that recognition of at le...
    • Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystemToll-like receptor 3 (TLR3) as was shown for mammals is expressed on myeloid dendritic cells, respiratory epithelium, macrophages, and appears to play a central role in mediating the antiviral and in...
    • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
    • Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemTLR5 is the receptor for flagellin, the protein that forms bacterial flagella. Unlike most other Pathogen-Associated Molecular Patterns (PAMPs), flagellin does not undergo any posttranslational modif...
    • Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystemRNA can serve as a danger signal, both in its double-stranded form (that is associated with viral infection), as well as single-stranded RNA (ssRNA). Specifically, guanosine (G)- and uridine (U)-rich...
    • Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemCpG DNA is an unusual Pathogen-Associated Molecular Pattern (PAMP). Cytosine methylation exists in mammalian but not bacterial cells, and most (but not all) CpG in the mammalian genome is methylated....
    • Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemTLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial...
    • Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemTLR2 and TLR4 recognize different bacterial cell wall components. While TLR4 is trained onto Gram-negative lipopolysaccharide components, TLR2 - in combination with TLR6 - plays a major role in recog...
    • Toll Receptor Cascades, organism-specific biosystem (from REACTOME)
      Toll Receptor Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
    • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
      Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Viral dsRNA:TLR3:TRIF Complex Activates RIP1, organism-specific biosystem (from REACTOME)
      Viral dsRNA:TLR3:TRIF Complex Activates RIP1, organism-specific biosystemReceptor-interacting protein 1 (RIP1) mediates the activation of interferon-alpha/beta via intermediate activation of IKK/TBK1 or NFkB pathways.
    • Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, organism-specific biosystem (from REACTOME)
      Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, organism-specific biosystemCell stimulation with viral ds RNA leads to the activation of two IKK-related serine/threonine kinases, TBK1 and IKK-i which directly phosphorylate IRF3 and IRF7 promoting their dimerization and tran...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    signal transducer activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    I-kappaB kinase/NF-kappaB cascade TAS
    Traceable Author Statement
    more info
    		  
    MyD88-dependent toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    MyD88-independent toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    TRIF-dependent toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    Toll signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    induction of apoptosis by extracellular signals IEA
    Inferred from Electronic Annotation
    more info
    		  
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    innate immune response TAS
    Traceable Author Statement
    more info
    		  
    lipopolysaccharide-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    macrophage activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of I-kappaB kinase/NF-kappaB cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of chemokine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of interferon-beta biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of type I interferon production IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to exogenous dsRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    toll-like receptor 1 signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    toll-like receptor 2 signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    toll-like receptor 3 signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    toll-like receptor 4 signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    endosome membrane TAS
    Traceable Author Statement
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    TIR domain-containing adapter molecule 1
    Names
    TIR domain-containing adapter molecule 1
    putative NF-kappa-B-activating protein 502H
    TIR domain containing adaptor inducing interferon-beta
    TIR domain-containing adapter protein inducing IFN-beta
    proline-rich, vinculin and TIR domain-containing protein B
    toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031998.1 RefSeqGene

      Range
      5001..20819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_182919.3 → NP_891549.1  TIR domain-containing adapter molecule 1

      Status: REVIEWED

      Source sequence(s)
      AB086380, AC027319, BC035331, BX349282, DR000002
      Consensus CDS
      CCDS12136.1
      UniProtKB/Swiss-Prot
      Q8IUC6
      Related
      ENSP00000248244, ENST00000248244
      Conserved Domains (2) summary
      pfam12721
      Location:675 – 698
      Blast Score: 92
      RHIM; RIP homotypic interaction motif
      cl15770
      Location:399 – 527
      Blast Score: 101
      TIR_2; TIR domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      4815938..4831737, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      4577652..4593355, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_014261.1: Suppressed sequence

      Description
      NM_014261.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC027319.5 (134738..137197) None
    genomic CQ871232.1 CAH56797.1
    mRNA AB086380.1 BAC55579.1
    mRNA AB093555.1 BAC44839.1
    mRNA AB097023.1 BAC77376.1
    mRNA AB446484.1 BAG55261.1
    mRNA AF070530.1 AAC28630.1
    mRNA AF492646.1 AAO85488.1
    mRNA BC009860.2 AAH09860.2
    mRNA BC035331.1 None
    mRNA BC136556.1 AAI36557.1
    mRNA BC136557.1 AAI36558.1
    mRNA BX349282.2 None
    mRNA CA308725.1 None
    mRNA DR000002.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IUC6.1 GenPept UniProtKB/Swiss-Prot:Q8IUC6
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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