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ORF1aTF 1aTF polyprotein [ Porcine reproductive and respiratory syndrome virus ]

Gene ID: 13905089, updated on 18-Aug-2023

Summary

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Gene symbol
ORF1aTF
Gene description
1aTF polyprotein
Locus tag
PRRSV_gp11
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Porcine reproductive and respiratory syndrome virus
Lineage
Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage; Nidovirales; Arteriviridae; unclassified Arteriviridae
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Genomic context

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Sequence:
NC_001961.1 (190..4396)

NC_001961.1Genomic Context describing neighboring genes Neighboring gene ORF1a polyprotein Neighboring gene ORF 1ab polyprotein Neighboring gene E protein Neighboring gene GP2 glycosylated envelope protein Neighboring gene GP3 envelope protein Neighboring gene GP4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001961.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The non-structural protein Nsp2TF of porcine reproductive and respiratory syndrome virus down-regulates the expression of Swine Leukocyte Antigen class I. Cao QM, et al. Virology, 2016 Apr. PMID 26895249
  2. Efficient -2 frameshifting by mammalian ribosomes to synthesize an additional arterivirus protein. Fang Y, et al. Proc Natl Acad Sci U S A, 2012 Oct 23. PMID 23043113, Free PMC Article
  3. North American and European porcine reproductive and respiratory syndrome viruses differ in non-structural protein coding regions. Allende R, et al. J Gen Virol, 1999 Feb. PMID 10073689
  4. Virus-encoded proteinases and proteolytic processing in the Nidovirales. Ziebuhr J, et al. J Gen Virol, 2000 Apr. PMID 10725411

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The last 68 amino acids of TF domain in Nsp2TF of porcine reproductive and respiratory syndrome virus are critical for down-regulates the expression of SLA-1.
    Title: The non-structural protein Nsp2TF of porcine reproductive and respiratory syndrome virus down-regulates the expression of Swine Leukocyte Antigen class I.
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General protein information

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Preferred Names
1aTF polyprotein
Names
nsp2TF protein
YP_006950436.1
  • product of -2 frameshift

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001961.1 Reference assembly

    Range
    190..4396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_006950436.1 1aTF polyprotein [Porcine reproductive and respiratory syndrome virus]

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A221C6B0
    Conserved Domains (5) summary
    pfam05412
    Location:428 → 535
    Peptidase_C33; Equine arterivirus Nsp2-type cysteine proteinase
    pfam05410
    Location:57 → 161
    Peptidase_C31; Porcine arterivirus-type cysteine proteinase alpha
    pfam05411
    Location:256 → 382
    Peptidase_C32; Equine arteritis virus putative proteinase
    pfam14756
    Location:536 → 682
    Pdase_C33_assoc; Peptidase_C33-associated domain
    pfam14757
    Location:804 → 1075
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein

  2. YP_006950437.1 nsp2TF protein

    UniProtKB/TrEMBL
    F2WZG2
    Conserved Domains (3) summary
    pfam05412
    Location:45 → 152
    Peptidase_C33; Equine arterivirus Nsp2-type cysteine proteinase
    pfam14756
    Location:153 → 299
    Pdase_C33_assoc; Peptidase_C33-associated domain
    pfam14757
    Location:421 → 692
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein

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