Slc26a3 solute carrier family 26, member 3 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Slc26a3provided by MGI
Official Full Name: solute carrier family 26, member 3provided by MGI
Primary source: MGI:107181
See related: Ensembl:ENSMUSG00000001225; Vega:OTTMUSG00000035459
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dra; AV376035; 9030623B18Rik; 9130013M11Rik
Summary: This gene encodes a member of the solute carrier/sulfate transporter family. The encoded protein is predominantly expressed in the intestine where it is essential for chloride absorption. Disruption of this gene results in chloride-rich diarrhea and compensatory up-regulation of ion-absorbing transporters. [provided by RefSeq, Dec 2012]

Genomic context

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Location :: 12 A3; 12 13.45 cM

Sequence :: Chromosome: 12; NC_000078.6 (31438301..31473719)

See Slc26a3 in Epigenomics, MapViewer

Chromosome 12 - NC_000078.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Endogenous and recombinant human/mouse Slc26a3 do not exhibit electrogenic 2Cl-/1HCO- exchange. Acute induction of Slc26a3 Cl-/HCO3- exchange is associated with secondary membrane potential changes representing homeostatic responses.
Title: Native and recombinant Slc26a3 (downregulated in adenoma, Dra) do not exhibit properties of 2Cl-/1HCO3- exchange.
This study showed a functionally active CFTR is an absolute requirement for Slc26-mediated duodenal bicarbonate secretion, but not for Slc26-mediated fluid absorption.
Title: The switch of intestinal Slc26 exchangers from anion absorptive to HCOFormula secretory mode is dependent on CFTR anion channel function.
demonstrate that the double-mutant mice present with a defect in intestinal water absorption and that Hnf1alpha and beta directly control the expression of Slc26a3.
Title: Hepatocyte nuclear factor 1alpha and beta control terminal differentiation and cell fate commitment in the gut epithelium.
Increase in DRA promoter activity and expression may contribute to the upregulation of intestinal electrolyte absorption and might underlie the potential antidiarrheal effects of Lactobacillus acidophilus.
Title: Lactobacillus acidophilus stimulates the expression of SLC26A3 via a transcriptional mechanism.
Decreased expression of colonic Slc26a3 and carbonic anhydrase iv as a cause of fatal infectious diarrhea in mice.
Title: Decreased expression of colonic Slc26a3 and carbonic anhydrase iv as a cause of fatal infectious diarrhea in mice.
Dra activity contributes most basal HCO(3)(-) secretion and approximately 50% of cAMP-stimulated HCO(3)(-) secretion in duodenum
Title: Role of down-regulated in adenoma anion exchanger in HCO3- secretion across murine duodenum.
slc26a3 is the major apical chloride/base exchanger and is essential for the absorption of chloride in the colon. In addition, slc26a3 regulates colonic crypt proliferation.
Title: slc26a3 (dra)-deficient mice display chloride-losing diarrhea, enhanced colonic proliferation, and distinct up-regulation of ion transporters in the colon.
In Slc26a6-knockout mice, a robust Slc26a3 compensatory upregulation can replace the function of Slc26a6 in pancreatic ducts.
Title: Effect of Slc26a6 deletion on apical Cl-/HCO3- exchanger activity and cAMP-stimulated bicarbonate secretion in pancreatic duct.

Submit: New GeneRIF Correction

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (1) 1 citation

Pathways from BioSystems

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Mineral absorption, organism-specific biosystem (from KEGG)
Mineral absorption, organism-specific biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
Mineral absorption, conserved biosystem (from KEGG)
Mineral absorption, conserved biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
Multifunctional anion exchangers, organism-specific biosystem (from REACTOME)
Multifunctional anion exchangers, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Pancreatic secretion, organism-specific biosystem (from KEGG)
Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
Pancreatic secretion, conserved biosystem (from KEGG)
Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
SLC-mediated transmembrane transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
Transmembrane transport of small molecules, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transport of inorganic cations/anions and amino acids/oligopeptides, organism-specific biosystem (from REACTOME)
Transport of inorganic cations/anions and amino acids/oligopeptides, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

AV376035 (e-PCR)
- UniSTS:180376

BQ203092 (e-PCR)
- UniSTS:260769

Homology

Homologs of the Slc26a3 gene: The Slc26a3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
anion:anion antiporter activity	IDA Inferred from Direct Assay more info	PubMed
anion:anion antiporter activity	ISO Inferred from Sequence Orthology more info
antiporter activity	IEA Inferred from Electronic Annotation more info
secondary active sulfate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
sulfate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
anion transport	IDA Inferred from Direct Assay more info	PubMed
ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
sulfate transport	IEA Inferred from Electronic Annotation more info
transmembrane transport	IEA Inferred from Electronic Annotation more info
transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
apical plasma membrane	ISO Inferred from Sequence Orthology more info
brush border membrane	ISO Inferred from Sequence Orthology more info
integral to membrane	IEA Inferred from Electronic Annotation more info
integral to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: chloride anion exchanger

Names: chloride anion exchanger; down-regulated in adenoma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021353.3 → NP_067328.1 chloride anion exchanger

Status: REVIEWED

Source sequence(s)

AK018566, BC139271, CR974423

Consensus CDS

CCDS25863.1

UniProtKB/Swiss-Prot

Q9WVC8

Related

ENSMUSP00000001254, OTTMUSP00000049827, ENSMUST00000001254, OTTMUST00000090744

Conserved Domains (3) summary

cd07042
Location:638 – 705
Blast Score: 151

STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function

pfam00916
Location:197 – 464
Blast Score: 469

Sulfate_transp; Sulfate transporter family

pfam13792
Location:58 – 130
Blast Score: 285

Sulfate_tra_GLY; Sulfate transporter N-terminal domain with GLY motif

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000078.6 Reference GRCm38.p1 C57BL/6J

Range

31438301..31473719

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000034.1 Alternate Mm_Celera

Range

32889209..32922999

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01098924.1	None
genomic	AAHY01098925.1	None
genomic	AAHY01098926.1	None
genomic	AAHY01098927.1	None
genomic	AAHY01098928.1 (17440..21460)	None
genomic	AC123618.26 (96327..131743)	None
genomic	CH466526.2	EDL36915.1	mixed
genomic	CR974423.21 (48732..84352)	None
mRNA	AF136751.1	AAD42784.1	FVB/N
mRNA	AK018566.1	None	C57BL/6J
mRNA	AK018617.1	None	C57BL/6J
mRNA	AK035716.1	None	C57BL/6J
mRNA	BC022639.1	AAH22639.1	FVB/N
mRNA	BC037066.1	AAH37066.1	FVB/N
mRNA	BC139271.1	AAI39272.1
mRNA	BC139273.1	AAI39274.1