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LOC1273006 presenilin homolog [ Anopheles gambiae (African malaria mosquito) ]

Gene ID: 1273006, updated on 10-May-2024

Summary

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Gene symbol
LOC1273006
Gene description
presenilin homolog
Gene type
protein coding
RefSeq status
MODEL
Organism
Anopheles gambiae
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae; Anophelinae; Anopheles
Orthologs
fruit fly all
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Genomic context

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Location:
chromosome: 2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_12 current idAnoGambNW_F1_1 (GCF_943734735.2) 2 NC_064601.1 (29993186..29996053, complement)

Chromosome 2 - NC_064601.1Genomic Context describing neighboring genes Neighboring gene leishmanolysin-like peptidase Neighboring gene splicing factor U2af 38 kDa subunit Neighboring gene transcription initiation factor IIA subunit 1 Neighboring gene squamous cell carcinoma antigen recognized by T-cells 3 Neighboring gene something about silencing protein 10

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_064601.1 Chromosome 2 Reference idAnoGambNW_F1_1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Anopheles gambiae genome: an update. Mongin E, et al. Trends Parasitol, 2004 Feb. PMID 14747013
  2. The genome sequence of the malaria mosquito Anopheles gambiae. Holt RA, et al. Science, 2002 Oct 4. PMID 12364791

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables aspartic endopeptidase activity, intramembrane cleaving IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch receptor processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in amyloid precursor protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in amyloid-beta metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in ciliary rootlet IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in dendritic shaft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
presenilin homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_943734735.2-RS_2023_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference idAnoGambNW_F1_1 Primary Assembly

Genomic

  1. NC_064601.1 Reference idAnoGambNW_F1_1 Primary Assembly

    Range
    29993186..29996053 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_061649659.1 → XP_061505643.1  presenilin homolog isoform X1

  2. XM_311942.6 → XP_311942.4  presenilin homolog isoform X2

    See identical proteins and their annotated locations for XP_311942.4

    UniProtKB/TrEMBL
    Q7PR98
    Conserved Domains (1) summary
    pfam01080
    Location:98 → 513
    Presenilin; Presenilin
Nucleotide Protein Strain
Heading Accession and Version

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Research Materials