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folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase protein FolK [ Streptococcus pyogenes MGAS15252 ]

Gene ID: 11991126, discontinued on 3-Feb-2015
  • All Gene records for this genome have been discontinued due to a change in scope for prokaryotic genomes in Gene. At the time this Gene record was discontinued, the RefSeq genome was re-annotated with the following features at this location:

Summary

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Gene symbol
folK
Gene description
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase protein FolK
Locus tag
MGAS15252_0826
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Streptococcus pyogenes MGAS15252 (strain: MGAS15252, nat-host: Homo sapiens)
Lineage
Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus
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Genomic regions, transcripts, and products

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Genomic Sequence:
NC_017040.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General protein information

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Names
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase protein FolK
YP_005388869.1
  • CDD hit: specific, cl233 = 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a carrier-mediated active transport system. Most microbes and plants lack this system and must synthesize folates de novo from guanosine triphosphate. One enzyme from this pathway is HPPK which catalyzes pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin (HP). The functional enzyme is a monomer. Mammals lack many of the enzymes in the folate pathway including, HPPK.

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_017040.1 Reference assembly

    Range
    811019..811519
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    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_005388869.1 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase protein FolK [Streptococcus pyogenes MGAS15252]

    Status: PROVISIONAL

Nucleotide Protein
Heading Accession and Version