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vav3 vav guanine nucleotide exchange factor 3 [ Astatotilapia calliptera (eastern happy) ]

Gene ID: 113028774, updated on 15-Mar-2024

Summary

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Gene symbol
vav3
Gene description
vav guanine nucleotide exchange factor 3
See related
Ensembl:ENSACLG00000014327
Gene type
protein coding
RefSeq status
MODEL
Organism
Astatotilapia calliptera
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; Pseudocrenilabrinae; Haplochromini; Astatotilapia
Orthologs
human zebrafish all
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Genomic context

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Location:
chromosome: 9
Exon count:
28
Annotation release Status Assembly Chr Location
100 current fAstCal1.2 (GCF_900246225.1) 9 NC_039310.1 (10011102..10103319)

Chromosome 9 - NC_039310.1Genomic Context describing neighboring genes Neighboring gene crystallin J1C-like Neighboring gene SH3-domain GRB2-like endophilin B1a Neighboring gene netrin g1a Neighboring gene protein arginine methyltransferase 6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_039310.1 Chromosome 9 Reference fAstCal1.2 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
guanine nucleotide exchange factor VAV3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Astatotilapia calliptera Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference fAstCal1.2 Primary Assembly

Genomic

  1. NC_039310.1 Reference fAstCal1.2 Primary Assembly

    Range
    10011102..10103319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_026179207.1 → XP_026034992.1  guanine nucleotide exchange factor VAV3 isoform X1

    UniProtKB/TrEMBL
    A0A3P8PVN6, A0A3P8PW35
    Related
    ENSACLP00000021063.1, ENSACLT00000021545.1
    Conserved Domains (7) summary
    cd11978
    Location:807 → 861
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd00029
    Location:518 → 562
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:197 → 373
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:387 → 510
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam11971
    Location:19 → 104
    CAMSAP_CH; CAMSAP CH domain
    cl15255
    Location:655 → 757
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:587 → 646
    SH3; Src Homology 3 domain superfamily

  2. XM_026179209.1 → XP_026034994.1  guanine nucleotide exchange factor VAV3 isoform X2

    UniProtKB/TrEMBL
    A0A3P8PW35, A0A3P8PW65
    Related
    ENSACLP00000021129.1, ENSACLT00000021618.1
    Conserved Domains (7) summary
    cd11978
    Location:780 → 834
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd00029
    Location:518 → 562
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:197 → 373
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:387 → 510
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam11971
    Location:19 → 104
    CAMSAP_CH; CAMSAP CH domain
    cl15255
    Location:655 → 757
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:587 → 646
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein
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