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ARHGEF28 Rho guanine nucleotide exchange factor 28 [ Canis lupus dingo (dingo) ]

Gene ID: 112659783, updated on 6-Jun-2024

Summary

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Gene symbol
ARHGEF28
Gene description
Rho guanine nucleotide exchange factor 28
See related
Ensembl:ENSCAFG00020017020
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus dingo (sub-species: dingo)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
45
Annotation release Status Assembly Chr Location
102 current ASM325472v2 (GCF_003254725.2) 2 NC_064244.1 (55061849..55350855)
101 previous assembly UNSW_AlpineDingo_1.0 (GCF_012295265.1) 2 Unlocalized Scaffold NW_023365054.1 (56369171..56658114)

Chromosome 2 - NC_064244.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat family A member 2 Neighboring gene UTP15 small subunit processome component Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC112660484 Neighboring gene ectodermal-neural cortex 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 28

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus dingo Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM325472v2

Genomic

  1. NC_064244.1 Reference ASM325472v2

    Range
    55061849..55350855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_035713570.2 → XP_035569463.2  rho guanine nucleotide exchange factor 28 isoform X4

    UniProtKB/TrEMBL
    A0A8I3MHH1

  2. XM_049103925.1 → XP_048959882.1  rho guanine nucleotide exchange factor 28 isoform X13

    UniProtKB/TrEMBL
    A0A8I3MDA7, A0A8P0TEK5

  3. XM_049103933.1 → XP_048959890.1  rho guanine nucleotide exchange factor 28 isoform X15

    UniProtKB/TrEMBL
    A0A8I3MDA7, A0A8P0TEK5

  4. XM_025446874.3 → XP_025302659.3  rho guanine nucleotide exchange factor 28 isoform X1

    UniProtKB/TrEMBL
    A0A8I3MHH1, A0A8P0NAG5

  5. XM_035713575.2 → XP_035569468.2  rho guanine nucleotide exchange factor 28 isoform X11

    UniProtKB/TrEMBL
    A0A8I3MDA7, A0A8P0TEK5

  6. XM_035713573.2 → XP_035569466.2  rho guanine nucleotide exchange factor 28 isoform X7

    UniProtKB/TrEMBL
    A0A8I3MHH1, A0A8P0NAG5

  7. XM_035713576.2 → XP_035569469.2  rho guanine nucleotide exchange factor 28 isoform X12

    UniProtKB/TrEMBL
    A0A8I3MDA7, A0A8P0TEK5

  8. XM_035713571.2 → XP_035569464.2  rho guanine nucleotide exchange factor 28 isoform X5

    UniProtKB/TrEMBL
    A0A8I3RPK7, A0A8P0P0C5

  9. XM_035713572.2 → XP_035569465.2  rho guanine nucleotide exchange factor 28 isoform X6

    UniProtKB/TrEMBL
    A0A8I3MXG3, A0A8P0NAP4

  10. XM_035713569.2 → XP_035569462.1  rho guanine nucleotide exchange factor 28 isoform X2

    UniProtKB/TrEMBL
    A0A8I3MHH1, A0A8P0NAG5
    Conserved Domains (4) summary
    smart00325
    Location:854 → 1043
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    COG4372
    Location:1419 → 1591
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    cd14680
    Location:1088 → 1188
    PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
    cd20876
    Location:647 → 707
    C1_p190RhoGEF; protein kinase C conserved region 1 (C1 domain) found in 190 kDa guanine nucleotide exchange factor (p190RhoGEF) and similar proteins

  11. XM_035713574.2 → XP_035569467.1  rho guanine nucleotide exchange factor 28 isoform X8

    UniProtKB/TrEMBL
    A0A8I3MHH1, A0A8P0NAG5
    Conserved Domains (4) summary
    smart00325
    Location:854 → 1043
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    COG4372
    Location:1353 → 1538
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    cd14680
    Location:1088 → 1188
    PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
    cd20876
    Location:647 → 707
    C1_p190RhoGEF; protein kinase C conserved region 1 (C1 domain) found in 190 kDa guanine nucleotide exchange factor (p190RhoGEF) and similar proteins

  12. XM_035713568.2 → XP_035569461.2  rho guanine nucleotide exchange factor 28 isoform X3

    UniProtKB/TrEMBL
    A0A8I3MHH1, A0A8P0NAG5

  13. XM_049103902.1 → XP_048959859.1  rho guanine nucleotide exchange factor 28 isoform X1

    UniProtKB/TrEMBL
    A0A8I3MHH1, A0A8P0NAG5

  14. XM_025446873.3 → XP_025302658.3  rho guanine nucleotide exchange factor 28 isoform X1

    UniProtKB/TrEMBL
    A0A8I3MHH1, A0A8P0NAG5

  15. XM_049103929.1 → XP_048959886.1  rho guanine nucleotide exchange factor 28 isoform X14

    UniProtKB/TrEMBL
    A0A8C0KX81

  16. XM_035713577.2 → XP_035569470.1  rho guanine nucleotide exchange factor 28 isoform X16

    UniProtKB/TrEMBL
    A0A8C0KX81
    Conserved Domains (4) summary
    PTZ00266
    Location:1090 → 1213
    PTZ00266; NIMA-related protein kinase; Provisional
    smart00325
    Location:476 → 665
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd20876
    Location:269 → 329
    C1_p190RhoGEF; protein kinase C conserved region 1 (C1 domain) found in 190 kDa guanine nucleotide exchange factor (p190RhoGEF) and similar proteins
    cl17171
    Location:710 → 810
    PH-like; Pleckstrin homology-like domain

  17. XM_025446887.3 → XP_025302672.1  rho guanine nucleotide exchange factor 28 isoform X16

    UniProtKB/TrEMBL
    A0A8C0KX81
    Related
    ENSCAFP00020021525.1
    Conserved Domains (4) summary
    PTZ00266
    Location:1090 → 1213
    PTZ00266; NIMA-related protein kinase; Provisional
    smart00325
    Location:476 → 665
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd20876
    Location:269 → 329
    C1_p190RhoGEF; protein kinase C conserved region 1 (C1 domain) found in 190 kDa guanine nucleotide exchange factor (p190RhoGEF) and similar proteins
    cl17171
    Location:710 → 810
    PH-like; Pleckstrin homology-like domain

  18. XM_025446884.3 → XP_025302669.1  rho guanine nucleotide exchange factor 28 isoform X9

    UniProtKB/TrEMBL
    A0A8C0KX81
    Conserved Domains (4) summary
    smart00325
    Location:540 → 729
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00029
    Location:340 → 385
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14680
    Location:774 → 874
    PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
    cl26472
    Location:1105 → 1277
    DUF3084; Protein of unknown function (DUF3084)

  19. XM_025446885.3 → XP_025302670.1  rho guanine nucleotide exchange factor 28 isoform X10

    UniProtKB/TrEMBL
    A0A8C0QFV5
    Related
    ENSCAFP00020021540.1
    Conserved Domains (4) summary
    smart00325
    Location:540 → 729
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00029
    Location:340 → 385
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl17171
    Location:774 → 874
    PH-like; Pleckstrin homology-like domain
    cl25917
    Location:1040 → 1185
    Exonuc_VII_L; Exonuclease VII, large subunit

  20. XM_025446886.3 → XP_025302671.1  rho guanine nucleotide exchange factor 28 isoform X16

    UniProtKB/TrEMBL
    A0A8C0KX81
    Conserved Domains (4) summary
    PTZ00266
    Location:1090 → 1213
    PTZ00266; NIMA-related protein kinase; Provisional
    smart00325
    Location:476 → 665
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd20876
    Location:269 → 329
    C1_p190RhoGEF; protein kinase C conserved region 1 (C1 domain) found in 190 kDa guanine nucleotide exchange factor (p190RhoGEF) and similar proteins
    cl17171
    Location:710 → 810
    PH-like; Pleckstrin homology-like domain

  21. XM_035713578.2 → XP_035569471.1  rho guanine nucleotide exchange factor 28 isoform X16

    UniProtKB/TrEMBL
    A0A8C0KX81
    Conserved Domains (4) summary
    PTZ00266
    Location:1090 → 1213
    PTZ00266; NIMA-related protein kinase; Provisional
    smart00325
    Location:476 → 665
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd20876
    Location:269 → 329
    C1_p190RhoGEF; protein kinase C conserved region 1 (C1 domain) found in 190 kDa guanine nucleotide exchange factor (p190RhoGEF) and similar proteins
    cl17171
    Location:710 → 810
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
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