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arhgap12b Rho GTPase activating protein 12b [ Oryzias melastigma (Indian medaka) ]

Gene ID: 112151009, updated on 10-Jul-2024

Summary

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Gene symbol
arhgap12b
Gene description
Rho GTPase activating protein 12b
See related
EnsemblRapid:ENSOMEG00005010445
Gene type
protein coding
RefSeq status
MODEL
Organism
Oryzias melastigma
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae; Oryzias
Also known as
arhgap12
Orthologs
human zebrafish all
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Genomic context

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Location:
chromosome: LG20
Exon count:
19
Annotation release Status Assembly LG Location
101 current ASM292280v2 (GCF_002922805.2) LG20 NC_050531.1 (19287546..19349982)
100 previous assembly Om_v0.7.RACA (GCF_002922805.1) Unplaced Scaffold NW_020096087.1 (4126301..4188910, complement)

Linkage Group LG20 - NC_050531.1Genomic Context describing neighboring genes Neighboring gene glucose-fructose oxidoreductase domain containing 1 Neighboring gene kinesin-1 heavy chain Neighboring gene zinc finger E-box binding homeobox 1b Neighboring gene uncharacterized LOC118600225 Neighboring gene zinc finger protein 438

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tissue-specific transcriptome assemblies of the marine medaka Oryzias melastigma and comparative analysis with the freshwater medaka Oryzias latipes. Lai KP, et al. BMC Genomics, 2015 Feb 27. PMID 25765076, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho GTPase-activating protein 12b
Names
Rho GTPase activating protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Oryzias melastigma Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM292280v2 Primary Assembly

Genomic

  1. NC_050531.1 Reference ASM292280v2 Primary Assembly

    Range
    19287546..19349982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024279599.2 → XP_024135367.1  rho GTPase-activating protein 12b isoform X3

    UniProtKB/TrEMBL
    A0A3B3CRM0
    Related
    ENSOMEP00005023284.1, ENSOMET00005025726.1
    Conserved Domains (6) summary
    cd12070
    Location:14 → 73
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd00201
    Location:258 → 286
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:641 → 827
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:450 → 562
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:356 → 381
    WW; WW domain
    pfam16618
    Location:70 → 240
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  2. XM_024279603.2 → XP_024135371.1  rho GTPase-activating protein 12b isoform X5

    UniProtKB/TrEMBL
    A0A3B3DZ51
    Related
    ENSOMEP00005023285.1, ENSOMET00005025727.1
    Conserved Domains (6) summary
    cd12070
    Location:14 → 73
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd00201
    Location:258 → 286
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:616 → 802
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:426 → 537
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:356 → 381
    WW; WW domain
    pfam16618
    Location:70 → 240
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  3. XM_024279597.2 → XP_024135365.1  rho GTPase-activating protein 12b isoform X1

    UniProtKB/TrEMBL
    A0A3B3CRM0, A0A3B3DZD7
    Related
    ENSOMEP00005023287.1, ENSOMET00005025729.1
    Conserved Domains (6) summary
    cd12070
    Location:14 → 73
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd00201
    Location:258 → 286
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:642 → 828
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:451 → 563
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:356 → 381
    WW; WW domain
    pfam16618
    Location:70 → 240
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  4. XM_024279600.2 → XP_024135368.1  rho GTPase-activating protein 12b isoform X2

    UniProtKB/TrEMBL
    A0A3B3CRM0
    Conserved Domains (6) summary
    cd12070
    Location:14 → 73
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd00201
    Location:258 → 286
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:641 → 827
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:451 → 562
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:356 → 381
    WW; WW domain
    pfam16618
    Location:70 → 240
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  5. XM_024279602.2 → XP_024135370.1  rho GTPase-activating protein 12b isoform X4

    UniProtKB/TrEMBL
    A0A3B3DZ51
    Related
    ENSOMEP00005023288.1, ENSOMET00005025730.1
    Conserved Domains (6) summary
    cd12070
    Location:14 → 73
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd00201
    Location:258 → 286
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:617 → 803
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:426 → 538
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:356 → 381
    WW; WW domain
    pfam16618
    Location:70 → 240
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  6. XM_024279598.2 → XP_024135366.1  rho GTPase-activating protein 12b isoform X1

    UniProtKB/TrEMBL
    A0A3B3CRM0, A0A3B3DZD7
    Related
    ENSOMEP00005023270.1, ENSOMET00005025712.1
    Conserved Domains (6) summary
    cd12070
    Location:14 → 73
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd00201
    Location:258 → 286
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:642 → 828
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:451 → 563
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00397
    Location:356 → 381
    WW; WW domain
    pfam16618
    Location:70 → 240
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
Nucleotide Protein Strain
Heading Accession and Version

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