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MTHFR methylenetetrahydrofolate reductase [ Neomonachus schauinslandi (Hawaiian monk seal) ]

Gene ID: 110574669, updated on 15-Mar-2024

Summary

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Gene symbol
MTHFR
Gene description
methylenetetrahydrofolate reductase
See related
EnsemblRapid:ENSNSCG00000007602
Gene type
protein coding
RefSeq status
MODEL
Organism
Neomonachus schauinslandi
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae; Neomonachus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
13
Annotation release Status Assembly Chr Location
101 current ASM220157v2 (GCF_002201575.2) 4 NC_058406.1 (8474642..8488706, complement)
100 previous assembly ASM220157v1 (GCF_002201575.1) Unplaced Scaffold NW_018734295.1 (8635294..8646957, complement)

Chromosome 4 - NC_058406.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA73 family Neighboring gene angiotensin II receptor associated protein Neighboring gene chromosome 4 C1orf167 homolog Neighboring gene chloride voltage-gated channel 6 Neighboring gene natriuretic peptide A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables FAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methylenetetrahydrofolate reductase (NAD(P)H) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
methylenetetrahydrofolate reductase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Neomonachus schauinslandi Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM220157v2

Genomic

  1. NC_058406.1 Reference ASM220157v2

    Range
    8474642..8488706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021683442.2 → XP_021539117.1  methylenetetrahydrofolate reductase isoform X2

    UniProtKB/TrEMBL
    A0A2Y9GJ70
    Related
    ENSNSCP00000009343.1
    Conserved Domains (1) summary
    cl00246
    Location:59 → 625
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

  2. XM_044913875.1 → XP_044769810.1  methylenetetrahydrofolate reductase isoform X1

    UniProtKB/TrEMBL
    A0A8M1M9W4
    Conserved Domains (1) summary
    cl00246
    Location:100 → 666
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
Nucleotide Protein
Heading Accession and Version

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