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Mthfr methylenetetrahydrofolate reductase [ Meriones unguiculatus (Mongolian gerbil) ]

Gene ID: 110555748, updated on 15-Mar-2024

Summary

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Gene symbol
Mthfr
Gene description
methylenetetrahydrofolate reductase
See related
EnsemblRapid:ENSMUGG00015023838
Gene type
protein coding
RefSeq status
MODEL
Organism
Meriones unguiculatus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Gerbillinae; Meriones
Orthologs
human mouse all
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Genomic context

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See Mthfr in Genome Data Viewer
Location:
chromosome: 3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current Bangor_MerUng_6.1 (GCF_030254825.1) 3 NC_083351.1 (7849806..7867574, complement)
100 previous assembly MunDraft-v1.0 (GCF_002204375.1) Unplaced Scaffold NW_018658454.1 (87350..103714, complement)

Chromosome 3 - NC_083351.1Genomic Context describing neighboring genes Neighboring gene angiotensin II receptor associated protein Neighboring gene chromosome 3 C1orf167 homolog Neighboring gene chloride voltage-gated channel 6 Neighboring gene natriuretic peptide A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables FAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methylenetetrahydrofolate reductase (NAD(P)H) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
methylenetetrahydrofolate reductase (NADPH)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_030254825.1-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Bangor_MerUng_6.1

Genomic

  1. NC_083351.1 Reference Bangor_MerUng_6.1

    Range
    7849806..7867574 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021649151.2 → XP_021504826.1  methylenetetrahydrofolate reductase (NADPH) isoform X4

    Related
    ENSMUGP00015034305.1, ENSMUGT00015043674.1
    Conserved Domains (1) summary
    cl00246
    Location:58 → 624
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

  2. XM_021649149.2 → XP_021504824.1  methylenetetrahydrofolate reductase (NADPH) isoform X4

    Conserved Domains (1) summary
    cl00246
    Location:58 → 624
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

  3. XM_060379100.1 → XP_060235083.1  methylenetetrahydrofolate reductase (NADPH) isoform X4

  4. XM_021649150.2 → XP_021504825.1  methylenetetrahydrofolate reductase (NADPH) isoform X4

    Conserved Domains (1) summary
    cl00246
    Location:58 → 624
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

  5. XM_021649148.2 → XP_021504823.1  methylenetetrahydrofolate reductase (NADPH) isoform X3

    Conserved Domains (1) summary
    cl00246
    Location:98 → 664
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

  6. XM_021649147.2 → XP_021504822.1  methylenetetrahydrofolate reductase (NADPH) isoform X2

    Related
    ENSMUGP00015034298.1, ENSMUGT00015043664.1
    Conserved Domains (1) summary
    cl00246
    Location:99 → 665
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

  7. XM_060379102.1 → XP_060235085.1  methylenetetrahydrofolate reductase (NADPH) isoform X6

  8. XM_060379101.1 → XP_060235084.1  methylenetetrahydrofolate reductase (NADPH) isoform X5

    Related
    ENSMUGP00015034315.1, ENSMUGT00015043687.1

  9. XM_021649146.2 → XP_021504821.1  methylenetetrahydrofolate reductase (NADPH) isoform X1

    Related
    ENSMUGP00015034293.1, ENSMUGT00015043656.1
    Conserved Domains (1) summary
    cl00246
    Location:103 → 669
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
Nucleotide Protein Strain
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