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SETDB1 SET domain bifurcated histone lysine methyltransferase 1 [ Lonchura striata (white-rumped munia) ]

Gene ID: 110476821, updated on 14-Aug-2024

Summary

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Gene symbol
SETDB1
Gene description
SET domain bifurcated histone lysine methyltransferase 1
Locus tag
RLOC_00010642
See related
Ensembl:ENSLSDG00000011947
Gene type
protein coding
RefSeq status
MODEL
Organism
Lonchura striata
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves; Passeriformes; Passeroidea; Estrildidae; Estrildinae; Lonchura
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 25
Exon count:
22
Annotation release Status Assembly Chr Location
101 current lonStrDom2 (GCF_005870125.1) 25 NC_042590.1 (274562..289480)
100 previous assembly LonStrDom1 (GCF_002197715.1) Unplaced Scaffold NW_018657054.1 (506729..521646, complement)

Chromosome 25 - NC_042590.1Genomic Context describing neighboring genes Neighboring gene aryl hydrocarbon receptor nuclear translocator Neighboring gene cortexin domain-containing 1-like Neighboring gene ceramide synthase 2 Neighboring gene MINDY lysine 48 deubiquitinase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histone H3K9 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in heterochromatin organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of DNA methylation-dependent heterochromatin formation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone-lysine N-methyltransferase SETDB1
Names
Histone-lysine N-methyltransferase SETDB1
SET domain bifurcated 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Lonchura striata domestica Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference lonStrDom2 Primary Assembly

Genomic

  1. NC_042590.1 Reference lonStrDom2 Primary Assembly

    Range
    274562..289480
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021542085.2 → XP_021397760.1  histone-lysine N-methyltransferase SETDB1

    UniProtKB/TrEMBL
    A0A218UE46
    Related
    ENSLSDP00000016602.1
    Conserved Domains (7) summary
    smart00391
    Location:595 → 670
    MBD; Methyl-CpG binding domain
    pfam18300
    Location:201 → 256
    DUF5604; Domain of unknown function (DUF5604)
    pfam18358
    Location:354 → 419
    Tudor_4; Histone methyltransferase Tudor domain
    pfam18359
    Location:265 → 313
    TUDOR_5; Histone methyltransferase Tudor domain 1
    cd10517
    Location:672 → 873
    SET_SETDB1; SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins
    cl02600
    Location:2 → 66
    HTH_MerR-SF; Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily
    cl40432
    Location:1195 → 1284
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
Nucleotide Protein
Heading Accession and Version

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