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IL4 interleukin 4 [ Numida meleagris (helmeted guineafowl) ]

Gene ID: 110405326, updated on 15-Mar-2024

Summary

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Gene symbol
IL4
Gene description
interleukin 4
See related
Ensembl:ENSNMEG00000020499
Gene type
protein coding
RefSeq status
MODEL
Organism
Numida meleagris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Numididae; Numida
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 12
Exon count:
7
Annotation release Status Assembly Chr Location
100 current NumMel1.0 (GCF_002078875.1) 12 NC_034420.1 (16503816..16508600)

Chromosome 12 - NC_034420.1Genomic Context describing neighboring genes Neighboring gene RAD50 double strand break repair protein Neighboring gene interleukin-4-like Neighboring gene kinesin family member 3A Neighboring gene cyclin I family member 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_034420.1 Chromosome 12 Reference NumMel1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables interleukin-4 receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell costimulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in T-helper 2 cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in activation of Janus kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response in mucosa IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in microglial cell activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in myeloid dendritic cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of T-helper 17 cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of acute inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of chronic inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of complement-dependent cytotoxicity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of endothelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of epithelial cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of macrophage activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MHC class II biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of T cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of amyloid-beta clearance IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of defense response to virus by host IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of eosinophil chemotaxis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of interleukin-10 production IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of interleukin-13 production IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of isotype switching to IgE isotypes IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of isotype switching to IgG isotypes IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of macroautophagy IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of mast cell degranulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of mononuclear cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of myoblast fusion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
interleukin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Numida meleagris Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NumMel1.0 Primary Assembly

Genomic

  1. NC_034420.1 Reference NumMel1.0 Primary Assembly

    Range
    16503816..16508600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021410543.1 → XP_021266218.1  interleukin-4

    Conserved Domains (1) summary
    cl11518
    Location:31 → 130
    IL4; Interleukin 4

  2. XM_021410541.1 → XP_021266216.1  interleukin-4

    Conserved Domains (1) summary
    cl11518
    Location:31 → 130
    IL4; Interleukin 4

  3. XM_021410545.1 → XP_021266220.1  interleukin-4

    Conserved Domains (1) summary
    cl11518
    Location:31 → 130
    IL4; Interleukin 4

  4. XM_021410542.1 → XP_021266217.1  interleukin-4

    Conserved Domains (1) summary
    cl11518
    Location:31 → 130
    IL4; Interleukin 4

  5. XM_021410544.1 → XP_021266219.1  interleukin-4

    Related
    ENSNMEP00000024104.1, ENSNMET00000035144.1
    Conserved Domains (1) summary
    cl11518
    Location:31 → 130
    IL4; Interleukin 4
Nucleotide Protein
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