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    YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide [ Homo sapiens ]

    Gene ID: 10971, updated on 5-Feb-2012
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    Summary

    Official Symbol
    YWHAQprovided by HGNC
    Official Full Name
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptideprovided by HGNC
    Primary source
    HGNC:12854
    See related
    Ensembl:ENSG00000134308; HPRD:00886; MIM:609009; Vega:OTTHUMG00000013848
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    1C5; HS1; 14-3-3
    Summary
    This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    2p25.1
    Sequence :
    Chromosome: 2; NC_000002.11 (9724106..9771106, complement)
    See YWHAQ in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100506357 Neighboring gene isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae) Neighboring gene ADAM metallopeptidase domain 17 Neighboring gene TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa Neighboring gene grainyhead-like 1 (Drosophila)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. 14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif. Andersen SD, et al. DNA Repair (Amst), 2012 Mar 1. PMID 22222486.
    2. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). Lopitz-Otsoa F, et al. J Proteomics, 2011 Dec 10. PMID 22178446.
    3. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    4. The role of 14-3-3β in transcriptional activation of estrogen receptor α and its involvement in proliferation of breast cancer cells. Kim Y, et al. Biochem Biophys Res Commun, 2011 Oct 14. PMID 21946067.
    5. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Li S, et al. Immunity, 2011 Sep 23. PMID 21903422.

    See all (156) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. 14-3-3beta has oncogenic potential in breast cancer via binding to ERalpha and activation of the transcriptional activity of ERalpha.
      Title: The role of 14-3-3β in transcriptional activation of estrogen receptor α and its involvement in proliferation of breast cancer cells.
    2. 14-3-3 theta is a new and important regulatory protein in the TLR-2 and TLR-4 signaling suppressing the MyD88-dependent pathway
      Title: Identification and functional characterization of 14-3-3 in TLR2 signaling.
    3. The phosphatidylinositol transfer protein RdgBbeta binds 14-3-3 via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II type I receptor-associated protein).
      Title: The phosphatidylinositol transfer protein RdgBβ binds 14-3-3 via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II type I receptor-associated protein).
    4. Results suggest that 14-3-3 proteins may be associated with the formation of SOD1-containing inclusions, in FALS patients and the mutant SOD1-Tg mice.
      Title: Colocalization of 14-3-3 proteins with SOD1 in Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis cases and the animal model.
    5. the toxin fusicoccin promotes binding of regulatory 14-3-3 proteins to glycoprotein Ibalpha and hampers binding to glycoprotein Ibbeta subunit.
      Title: The phytotoxin fusicoccin promotes platelet aggregation via 14-3-3-glycoprotein Ib-IX-V interaction.
    6. novel role for 14-3-3tau in the regulation of Beclin 1 expression and autophagy
      Title: 14-3-3Tau regulates Beclin 1 and is required for autophagy.
    7. Depletion of Lats2 or 14-3-3gamma by siRNA inhibits P-body formation in response to UV.
      Title: A novel Chk1/2-Lats2-14-3-3 signaling pathway regulates P-body formation in response to UV damage.
    8. The study found that the 14-3-3 tau expression level with the formation of syncytiotrophoblast cells increased.
      Title: Differential protein expression level identification by knockout of 14-3-3τ with siRNA technique and 2DE followed MALDI-TOF-TOF-MS.
    9. Findings suggest that modulating the C-RAFSer(259)/14-3-3 protein-protein interaction with a stabilizing small molecule may yield a novel potential approach for treatment of diseases resulting from an overactive Ras-RAF-MAPK pathway.
      Title: Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.
    10. Data show that distinct phosphatases dephosphorylate conserved AKT motifs within the FOXO family and that PP2A is entwined in a dynamic interplay with AKT and 14-3-3 to directly regulate FOXO3a subcellular localization and transcriptional activation.
      Title: Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT.
    Submit: New GeneRIF Correction See all (48)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr inhibits insulin-induced association of 14-3-3 and Foxo3a in HeLa cells PubMed
    vpr Yeast two-hybrid assays show that the C-terminal half (residues 141-244) of 14-3-3 tau binds to HIV-1 Vpr; Vpr supports triple complex formation with 14-3-3 tau and Cdc25C PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_006817.1 NP_036427.1 CABIN1    BIND  PubMed YWHAQ (14-3-3-theta) interacts with phosphorylated CABIN1. This interaction was modelled on a demonstrated interaction between mouse 14-3-3-theta and human CABIN1. 
    NP_006817.1 AAA19586.1 CDK11B    BIND  PubMed CDK11-p110 interacts with 14-3-3-theta. 
    NP_006817.1 NP_000359.1 TSC1    BIND  PubMed Hamartin interacts with 14-3-3-tau. This interaction is modeled on demonstrated interaction between human hamartin and mouse 14-3-3-tau isoform. 
    NP_006817.1 NP_000539.1 TSC2    BIND  PubMed Tumor suppressor protein tuberin interacts with 14-3-3-tau isoform. This interaction is modeled on demonstrated interaction between human tuberin and mouse 14-3-3-tau isoform. 
    NP_006817.1 NP_003346.2 UCP2    BIND  PubMed UCP2 interacts with 14.3.3-theta. 
    NP_006817.1 NP_003347.1 UCP3    BIND  PubMed UCP3 interacts with 14.3.3-theta. 
    P27348 P00519 ABL1    HPRD  PubMed  
    P27348 Q92934 BAD    HPRD  PubMed  
    P27348 Q07814 BAX    HPRD  PubMed  
    P27348 P11274 BCR    HPRD  PubMed  
    P27348 P15056 BRAF    HPRD  PubMed  
    P27348 Q9Y6J0 CABIN1    HPRD  PubMed  
    P27348 P20807 CAPN3    HPRD  PubMed  
    P27348 P22681 CBL    HPRD  PubMed  
    P27348 P30305 CDC25B    HPRD  PubMed  
    P27348 P30307 CDC25C    HPRD  PubMed  
    P27348 P21127 CDK11B    HPRD  PubMed  
    P27348 O94921 CDK14    HPRD  PubMed  
    P27348 P46527 CDKN1B    HPRD  PubMed  
    P27348 P48729 CSNK1A1    HPRD  PubMed  
    P27348 P68400 CSNK2A1    HPRD  PubMed  
    P27348 P38919 EIF4A3    HPRD  PubMed  
    P27348 P11171 EPB41    HPRD  PubMed  
    P27348 Q9H4G0 EPB41L1    HPRD  PubMed  
    P27348 Q9Y2J2 EPB41L3    HPRD  PubMed  
    P27348 P09769 FGR    HPRD  PubMed  
    P27348 P23945 FSHR    HPRD  PubMed  
    P27348 O00165 HAX1    HPRD  PubMed  
    P27348 Q8WUI4 HDAC7    HPRD  PubMed  
    P27348 Heat shock 70 KD protein 1A HSPA1A    HPRD  PubMed  
    P27348 P11142 HSPA8    HPRD  PubMed  
    P27348 Q9UK53 ING1    HPRD  PubMed  
    P27348 P16144 ITGB4    HPRD  PubMed  
    P27348 Q9H427 KCNK15    HPRD  PubMed  
    P27348 O14649 KCNK3    HPRD  PubMed  
    P27348 Q9NPC2 KCNK9    HPRD  PubMed  
    P27348 P33176 KIF5B    HPRD  PubMed  
    P27348 Q9H0B6 KLC2    HPRD  PubMed  
    P27348 Q6P597 KLC3    HPRD  PubMed  
    P27348 P04264 KRT1    HPRD  PubMed  
    P27348 P35527 KRT9    HPRD  PubMed  
    P27348 Q6PKG0 LARP1    HPRD  PubMed  
    P27348 Q99698 LYST    HPRD  PubMed  
    P27348 P61326 MAGOH    HPRD  PubMed  
    P27348 Q99759 MAP3K3    HPRD  PubMed  
    P27348 Q99683 MAP3K5    HPRD  PubMed  
    P27348 O15151 MDM4    HPRD  PubMed  
    P27348 Q14814 MEF2D    HPRD  PubMed  
    P27348 Q04912 MST1R    HPRD  PubMed  
    P27348 P49286 MTNR1B    HPRD  PubMed  
    P27348 P42345 MTOR    HPRD  PubMed  
    P27348 Q13469 NFATC2    HPRD  PubMed  
    P27348 Q14934 NFATC4    HPRD  PubMed  
    P27348 Q9GZT8 NIF3L1    HPRD  PubMed  
    P27348 Q15118 PDK1    HPRD  PubMed  
    P27348 O15530 PDPK1    HPRD  PubMed  
    P27348 O60825 PFKFB2    HPRD  PubMed  
    P27348 Q9UBF8 PI4KB    HPRD  PubMed  
    P27348 P42338 PIK3CB    HPRD  PubMed  
    P27348 Q15139 PRKD1    HPRD  PubMed  
    P27348 O14744 PRMT5    HPRD  PubMed  
    P27348 Q9P0K7 RAI14    HPRD  PubMed  
    P27348 O75628 REM1    HPRD  PubMed  
    P27348 P49796 RGS3    HPRD  PubMed  
    P27348 P49802 RGS7    HPRD  PubMed  
    P27348 P78314 SH3BP2    HPRD  PubMed  
    P27348 P32418 SLC8A1    HPRD  PubMed  
    P27348 Q9UPR5 SLC8A2    HPRD  PubMed  
    P27348 P57103 SLC8A3    HPRD  PubMed  
    P27348 O15198 SMAD9    HPRD  PubMed  
    P27348 P84103 SRSF3    HPRD  PubMed  
    P27348 O14746 TERT    HPRD  PubMed  
    P27348 P12270 TPR    HPRD  PubMed  
    P27348 Q92574 TSC1    HPRD  PubMed  
    P27348 P49815 TSC2    HPRD  PubMed  
    P27348 Q13748 TUBA3C    HPRD  PubMed  
    P27348 Q9NRR5 UBQLN4    HPRD  PubMed  
    P27348 P55851 UCP2    HPRD  PubMed  
    P27348 P55916 UCP3    HPRD  PubMed  
    P27348 P40818 USP8    HPRD  PubMed  
    P27348 Q9BQA1 WDR77    HPRD  PubMed  
    P27348 P46937 YAP1    HPRD  PubMed  
    P27348 P61981 YWHAG    HPRD  PubMed  
    P27348 P27348 YWHAQ    HPRD  PubMed  
    BioGRID:116168 BioGRID:121569 AARS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:108478 ACSL4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:106574 ACTA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:106575 ACTB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:106586 ACTG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:106603 ACTN2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:124782 ADCK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:106650 ADORA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:106696 AHCY    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:124059 AKT1S1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:128979 ANKRD18A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:106798 ANXA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:106799 ANXA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:106821 APC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:106862 AR    BioGRID  PubMed Reconstituted Complex 
    BioGRID:116168 BioGRID:122784 ARHGAP10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:118085 ARHGEF16    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:114618 ARHGEF2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116168 BioGRID:106987 ATP5A1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:106994 ATP5B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:107048 BAD    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:116168 BioGRID:120354 BANK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:107057 BAX    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:116168 BioGRID:115437 BCAP31    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:107141 BRAF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:117070 CABIN1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116168 BioGRID:107233 CACNA1S    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:107252 CALM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:119732 CALML5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:107265 CAMK2A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116168 BioGRID:107315 CBL    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:116168 BioGRID:122960 CBLL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:127299 CBWD2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:120867 CCAR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116168 BioGRID:107428 CDC25A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116168 BioGRID:107429 CDC25B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:116168 BioGRID:107424 CDC5L    BioGRID  PubMed Two-hybrid 
    BioGRID:116168 BioGRID:111154 CDK16    BioGRID  PubMed Two-hybrid 
    BioGRID:116168 BioGRID:111155 CDK17    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:116168 BioGRID:111156 CDK18    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:116168 BioGRID:107461 CDKN1B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116168 BioGRID:115193 CEP170    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:116360 CEP250    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:107499 CFL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:115349 CHAF1A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:116168 BioGRID:107578 CKM    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:107623 CLTC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:119324 COPS4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:107764 CPS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:128308 CRTC2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:116168 BioGRID:107821 CSE1L    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:107883 CTPS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:107982 DAPK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116168 BioGRID:118787 DCPS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:108019 DDX1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:108020 DDX3X    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:108022 DDX6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:115552 DENND4A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:108038 DES    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:108025 DHX9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:118061 DISC1    BioGRID  PubMed Two-hybrid 
    BioGRID:116168 BioGRID:108123 DNMT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:108117 DYNC1H1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:108201 E2F1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:116168 BioGRID:123144 EDC3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:108237 EEF1A1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:115119 EIF4A3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:108325 EMD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:129161 EML3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:108338 ENO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:108351 EPB41L2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:116753 EPB41L3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:108403 ESR1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:116168 BioGRID:108404 ESR2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:116168 BioGRID:114602 EXO1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:116168 BioGRID:569917 FAM83G    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:108488 FASN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:112508 FSCN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:111363 FXYD1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:116168 BioGRID:108868 GAPDH    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:116181 GCN1L1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:109260 H1F0    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:109268 H2AFX    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:109280 HADHA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:114092 HAT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:115106 HDAC4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Two-hybrid 
    BioGRID:116168 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Two-hybrid 
    BioGRID:116168 BioGRID:119613 HDAC7    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Two-hybrid 
    BioGRID:116168 BioGRID:109261 HIST1H1C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:109262 HIST1H1D    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:109265 HIST1H1T    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:113926 HIST1H2AK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:109270 HIST1H2BD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:113935 HIST1H2BG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:113955 HIST1H4A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:126025 HIST2H3C    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116168 BioGRID:113966 HIST2H4A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:109401 HMGCS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:109420 HNRNPA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:109422 HNRNPA2B1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:109424 HNRNPC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:109426 HNRNPF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:109428 HNRNPH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:109431 HNRNPK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:109544 HSPA8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:109547 HSPB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:109596 HUS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:120824 IARS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:109833 ING1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:116168 BioGRID:114353 IQGAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:114209 IRS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:116904 KIAA0930    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:117452 KIAA1429    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:114873 KIF23    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:110000 KIF5B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:110001 KIF5C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:122313 KLC2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:124648 KLC4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:110046 KRT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:110070 KRT17    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:110073 KRT18    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:116168 BioGRID:110054 KRT8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:110055 KRT9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:116947 LARP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:116968 LARS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:110131 LDHA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:115855 LEPREL4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:119559 LIMA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:110186 LMNA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:110187 LMNB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:110193 LMO7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:119646 LUC7L2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:107552 LYST    BioGRID  PubMed Two-hybrid 
    BioGRID:116168 BioGRID:110290 MAGOH    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:108326 MARK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:110310 MARK3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:110340 MCM3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116168 BioGRID:111465 MED1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:116168 BioGRID:110373 MEF2D    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:116168 BioGRID:110447 MLLT4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:116776 MPRIP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:116731 MRPS27    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:108757 MTOR    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:116709 MYCBP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:110714 MYH11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:114272 MYH13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:110705 MYH2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:110710 MYH7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:110712 MYH9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:125182 MYL12B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:110718 MYL3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:124494 MYLK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:208443 Mlxipl    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:116168 BioGRID:122408 NADK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:110771 NCL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:114200 NCOA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:116168 BioGRID:113841 NCOA3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:116168 BioGRID:120175 NDE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:110845 NFATC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:121922 NIF3L1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116168 BioGRID:118963 NME7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:114654 NOLC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:110929 NPM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:113843 NRIP1    BioGRID  PubMed Co-localization; Phenotypic Suppression; Reconstituted Complex 
    BioGRID:116168 BioGRID:110980 NUMA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:115436 OPTN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:114296 PABPC4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:113777 PABPN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:115586 PAK4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:121251 PAK6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:119751 PANK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:123079 PANK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:111136 PCK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:111139 PCM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:115333 PDCD6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:111165 PDE3A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:111196 PDPK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116168 BioGRID:114135 PDXK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:111229 PFKFB2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:116168 BioGRID:111232 PFKL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:111237 PFN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:111251 PGK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:124661 PHLDB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:111316 PI4KB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:111305 PIK3C2B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:111332 PKM2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:116440 PNKP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:114068 PPFIBP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:111089 PRDX1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:111576 PRKCZ    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:116168 BioGRID:111573 PRKD1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:116168 BioGRID:111577 PRKDC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:115492 PSME3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:111740 PTPN3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:114583 RABEP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:111831 RAF1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:116168 BioGRID:117526 RAI14    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:116575 RALY    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:117315 RASGRP3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:118781 REM1    BioGRID  PubMed Far Western 
    BioGRID:116168 BioGRID:111913 RFC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:111965 RNASE2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:110813 RPL10A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:112058 RPL15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:112063 RPL19    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:112064 RPL21    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:112049 RPL7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:112094 RPLP0    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:112096 RPLP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:112102 RPS3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:116067 RUVBL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:120407 SAMD4B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:122054 SAMSN1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:116168 BioGRID:109072 SFN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:117194 SH3BP4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:116194 SLC27A2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:112519 SNRPE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:121237 SPIRE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:112575 SPR    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:112586 SPTA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:112588 SPTB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:112324 SRSF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:115990 SRSF10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:112326 SRSF3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:112329 SRSF6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:112620 SSBP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:119300 SUV420H1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:112810 TCP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:112874 TERT    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:116168 BioGRID:124750 TGIF2LY    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:112923 THRA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:116168 BioGRID:114809 TJP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:112949 TLN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:113012 TP53BP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:113020 TPI1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:113021 TPM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:115457 TRIM28    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:113100 TSC2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:116168 BioGRID:113124 TTN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:113603 TUBA1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:124259 TUBA1C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:113129 TUBA3C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:128444 TUBB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:113131 TUBB2A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:122325 TUT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:116168 BioGRID:113198 UCP2    BioGRID  PubMed Two-hybrid 
    BioGRID:116168 BioGRID:113199 UCP3    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:116168 BioGRID:121631 UNC79    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:123904 USP42    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:114555 USP8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:113250 VARS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:113251 VASP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:113272 VIM    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:123255 WDR61    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:113303 WEE1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:116168 BioGRID:122421 WNK4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:114957 WTAP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:123070 WWC2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:116243 WWP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:115684 YAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:113361 YWHAB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:113363 YWHAE    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:116168 BioGRID:113364 YWHAG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:113365 YWHAH    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:113366 YWHAZ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116168 BioGRID:116719 ZC3H13    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein N-terminus binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    negative regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein targeting IEA
    Inferred from Electronic Annotation
    more info
    		  
    small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    soluble fraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    14-3-3 protein theta
    Names
    14-3-3 protein theta
    protein tau
    14-3-3 protein tau
    14-3-3 protein T-cell
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006826.2 → NP_006817.1  14-3-3 protein theta

      Status: REVIEWED

      Source sequence(s)
      X56468, X57347
      Consensus CDS
      CCDS1666.1
      UniProtKB/Swiss-Prot
      P27348
      Related
      ENSP00000238081, OTTHUMP00000015730, ENST00000238081, OTTHUMT00000038868
      Conserved Domains (1) summary
      cd10023
      Location:1 – 229
      Blast Score: 1074
      14-3-3_theta; 14-3-3 theta/tau (theta in mice, tau in human), an isoform of 14-3-3 protein

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      9724106..9771106, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      9569619..9616586, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC073195.5 AAX93143.1
    genomic AC082651.6 AAY24326.1
    genomic CH471053.2 EAX00977.1
      EAX00978.1
      EAX00979.1
    genomic CS185527.1 CAJ42708.1
    mRNA AF070556.1 AAC28640.1
    mRNA AK297624.1 BAG60000.1
    mRNA AK302208.1 BAG63566.1
    mRNA AK309462.1 None
    mRNA AK316158.1 BAH14529.1
    mRNA BC001197.1 None
    mRNA BC050601.1 AAH50601.1
    mRNA BC056867.1 AAH56867.1
    mRNA BC093019.1 AAH93019.1
    mRNA BT020014.1 AAV38817.1
    mRNA X56468.1 CAA39840.1
    mRNA X57347.1 CAA40622.1
    other-genetic AM393330.1 CAL38208.1
    other-genetic AM393338.1 CAL38216.1
    other-genetic AM393358.1 CAL38236.1
    other-genetic AM393674.1 CAL38550.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P27348.1 GenPept UniProtKB/Swiss-Prot:P27348
    Q53RR5 GenPept UniProtKB/TrEMBL:Q53RR5
    Q53S41 GenPept UniProtKB/TrEMBL:Q53S41
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

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