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ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor 6 [ Manis javanica (Malayan pangolin) ]

Gene ID: 108410087, updated on 14-Mar-2024

Summary

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Gene symbol
ARHGEF6
Gene description
Rac/Cdc42 guanine nucleotide exchange factor 6
Gene type
protein coding
RefSeq status
MODEL
Organism
Manis javanica
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Pholidota; Manidae; Manis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
22
Annotation release Status Assembly Chr Location
101 current YNU_ManJav_2.0 (GCF_014570535.1) Unplaced Scaffold NW_023436009.1 (8963105..9057404, complement)
100 previous assembly ManJav1.0 (GCF_001685135.1) Unplaced Scaffold NW_016548102.1 (64543..159434, complement)

NW_023436009.1Genomic Context describing neighboring genes Neighboring gene vestigial like family member 1 Neighboring gene CD40 ligand Neighboring gene 40S ribosomal protein S25-like Neighboring gene 60S ribosomal protein L39-like Neighboring gene small nucleolar RNA SNORD61 Neighboring gene RNA binding motif protein X-linked

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 6

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Manis javanica Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference YNU_ManJav_2.0 Primary Assembly

Genomic

  1. NW_023436009.1 Reference YNU_ManJav_2.0 Primary Assembly

    Range
    8963105..9057404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_037016879.1 → XP_036872774.1  rho guanine nucleotide exchange factor 6 isoform X4

    Conserved Domains (7) summary
    cd12060
    Location:162 → 219
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    cd00160
    Location:242 → 431
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:462 → 559
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:590 → 694
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16523
    Location:697 → 783
    betaPIX_CC; betaPIX coiled coil
    pfam16615
    Location:115 → 160
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    cd21265
    Location:1 → 117
    CH_alphaPIX; calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor

  2. XM_037016882.1 → XP_036872777.1  rho guanine nucleotide exchange factor 6 isoform X8

    Conserved Domains (7) summary
    cd12060
    Location:162 → 219
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    cd00160
    Location:242 → 419
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:450 → 547
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:578 → 675
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16523
    Location:678 → 764
    betaPIX_CC; betaPIX coiled coil
    pfam16615
    Location:115 → 160
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    cd21265
    Location:1 → 117
    CH_alphaPIX; calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor

  3. XM_037016881.1 → XP_036872776.1  rho guanine nucleotide exchange factor 6 isoform X6

    Conserved Domains (7) summary
    cd12060
    Location:162 → 219
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    cd00160
    Location:242 → 431
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:462 → 559
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:584 → 641
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16523
    Location:644 → 730
    betaPIX_CC; betaPIX coiled coil
    pfam16615
    Location:115 → 160
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    cd21265
    Location:1 → 117
    CH_alphaPIX; calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor

  4. XM_037016880.1 → XP_036872775.1  rho guanine nucleotide exchange factor 6 isoform X5

    Conserved Domains (7) summary
    cd12060
    Location:162 → 219
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    cd00160
    Location:242 → 431
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:462 → 559
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:581 → 648
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16523
    Location:651 → 737
    betaPIX_CC; betaPIX coiled coil
    pfam16615
    Location:115 → 160
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    cd21265
    Location:1 → 117
    CH_alphaPIX; calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor

  5. XM_037016877.1 → XP_036872772.1  rho guanine nucleotide exchange factor 6 isoform X2

    Conserved Domains (7) summary
    cd12060
    Location:162 → 219
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    cd00160
    Location:242 → 431
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:462 → 559
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:590 → 687
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16523
    Location:690 → 776
    betaPIX_CC; betaPIX coiled coil
    pfam16615
    Location:115 → 160
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    cd21265
    Location:1 → 117
    CH_alphaPIX; calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor

  6. XM_017681043.2 → XP_017536532.1  rho guanine nucleotide exchange factor 6 isoform X7

  7. XM_037016878.1 → XP_036872773.1  rho guanine nucleotide exchange factor 6 isoform X3

    Conserved Domains (7) summary
    cd12060
    Location:162 → 219
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    cd00160
    Location:242 → 419
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:450 → 547
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:578 → 682
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16523
    Location:685 → 771
    betaPIX_CC; betaPIX coiled coil
    pfam16615
    Location:115 → 160
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    cd21265
    Location:1 → 117
    CH_alphaPIX; calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor

  8. XM_037016876.1 → XP_036872771.1  rho guanine nucleotide exchange factor 6 isoform X1

    Conserved Domains (7) summary
    cd12060
    Location:162 → 219
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    cd00160
    Location:242 → 431
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:462 → 559
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:585 → 690
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16523
    Location:693 → 779
    betaPIX_CC; betaPIX coiled coil
    pfam16615
    Location:115 → 160
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    cd21265
    Location:1 → 117
    CH_alphaPIX; calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor
Nucleotide Protein
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