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SETDB2 SET domain bifurcated histone lysine methyltransferase 2 [ Manis javanica (Malayan pangolin) ]

Gene ID: 108403560, updated on 14-Mar-2024

Summary

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Gene symbol
SETDB2
Gene description
SET domain bifurcated histone lysine methyltransferase 2
Gene type
protein coding
RefSeq status
MODEL
Organism
Manis javanica
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Pholidota; Manidae; Manis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
15
Annotation release Status Assembly Chr Location
101 current YNU_ManJav_2.0 (GCF_014570535.1) Unplaced Scaffold NW_023435910.1 (38802501..38875580, complement)
100 previous assembly ManJav1.0 (GCF_001685135.1) Unplaced Scaffold NW_016538353.1 (4892..75890)

NW_023435910.1Genomic Context describing neighboring genes Neighboring gene SEH1 like nucleoporin Neighboring gene protein tyrosine phosphatase non-receptor type 2 Neighboring gene small nuclear ribonucleoprotein G-like Neighboring gene uncharacterized LOC118973801 Neighboring gene calcium binding protein 39 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histone H3K9 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in heterochromatin organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of DNA methylation-dependent heterochromatin formation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone-lysine N-methyltransferase SETDB2
Names
SET domain bifurcated 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Manis javanica Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference YNU_ManJav_2.0 Primary Assembly

Genomic

  1. NW_023435910.1 Reference YNU_ManJav_2.0 Primary Assembly

    Range
    38802501..38875580 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_037025769.1 → XP_036881664.1  histone-lysine N-methyltransferase SETDB2 isoform X5

    Conserved Domains (2) summary
    cd01395
    Location:152 → 212
    HMT_MBD; Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated ...
    cl40432
    Location:210 → 420
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  2. XM_037025749.1 → XP_036881644.1  histone-lysine N-methyltransferase SETDB2 isoform X2

    Conserved Domains (2) summary
    cd01395
    Location:152 → 212
    HMT_MBD; Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated ...
    cd10523
    Location:210 → 702
    SET_SETDB2; SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins

  3. XM_037025757.1 → XP_036881652.1  histone-lysine N-methyltransferase SETDB2 isoform X3

    Conserved Domains (2) summary
    cd01395
    Location:152 → 212
    HMT_MBD; Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated ...
    cd10523
    Location:210 → 702
    SET_SETDB2; SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins

  4. XM_017670763.2 → XP_017526252.1  histone-lysine N-methyltransferase SETDB2 isoform X4

  5. XM_017670762.2 → XP_017526251.1  histone-lysine N-methyltransferase SETDB2 isoform X1

    Conserved Domains (2) summary
    cd01395
    Location:152 → 212
    HMT_MBD; Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated ...
    cd10523
    Location:210 → 702
    SET_SETDB2; SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins
Nucleotide Protein
Heading Accession and Version

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