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PCSK5 proprotein convertase subtilisin/kexin type 5 [ Manis javanica (Malayan pangolin) ]

Gene ID: 108399493, updated on 14-Mar-2024

Summary

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Gene symbol
PCSK5
Gene description
proprotein convertase subtilisin/kexin type 5
Gene type
protein coding
RefSeq status
MODEL
Organism
Manis javanica
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Pholidota; Manidae; Manis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
40
Annotation release Status Assembly Chr Location
101 current YNU_ManJav_2.0 (GCF_014570535.1) Unplaced Scaffold NW_023436132.1 (10353644..10801642, complement)
100 previous assembly ManJav1.0 (GCF_001685135.1) Unplaced Scaffold NW_016534874.1 (53504..494625)

NW_023436132.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118967054 Neighboring gene riboflavin kinase Neighboring gene uncharacterized LOC118967066 Neighboring gene uncharacterized LOC118967049

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptide hormone processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
proprotein convertase subtilisin/kexin type 5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Manis javanica Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference YNU_ManJav_2.0 Primary Assembly

Genomic

  1. NW_023436132.1 Reference YNU_ManJav_2.0 Primary Assembly

    Range
    10353644..10801642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017664306.2 → XP_017519795.2  proprotein convertase subtilisin/kexin type 5 isoform X2

    Conserved Domains (8) summary
    pfam03302
    Location:1263 → 1548
    VSP; Giardia variant-specific surface protein
    cd04059
    Location:125 → 419
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:781 → 822
    FU; Furin-like repeats
    cd00064
    Location:1568 → 1617
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam01483
    Location:504 → 594
    P_proprotein; Proprotein convertase P-domain
    pfam14843
    Location:634 → 743
    GF_recep_IV; Growth factor receptor domain IV
    pfam15913
    Location:1209 → 1277
    Furin-like_2; Furin-like repeat, cysteine-rich
    pfam16470
    Location:37 → 113
    S8_pro-domain; Peptidase S8 pro-domain

  2. XM_017664305.2 → XP_017519794.2  proprotein convertase subtilisin/kexin type 5 isoform X1

    Conserved Domains (8) summary
    pfam03302
    Location:1290 → 1575
    VSP; Giardia variant-specific surface protein
    cd04059
    Location:125 → 419
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:781 → 822
    FU; Furin-like repeats
    cd00064
    Location:1595 → 1644
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:844 → 991
    Furin-like; Furin-like cysteine rich region
    pfam01483
    Location:504 → 594
    P_proprotein; Proprotein convertase P-domain
    pfam14843
    Location:634 → 743
    GF_recep_IV; Growth factor receptor domain IV
    pfam16470
    Location:37 → 113
    S8_pro-domain; Peptidase S8 pro-domain

  3. XM_036991294.1 → XP_036847189.1  proprotein convertase subtilisin/kexin type 5 isoform X6

    Conserved Domains (7) summary
    pfam03302
    Location:1221 → 1506
    VSP; Giardia variant-specific surface protein
    cd04059
    Location:125 → 419
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:1571 → 1615
    FU; Furin-like repeats
    cd00064
    Location:1526 → 1575
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam01483
    Location:504 → 594
    P_proprotein; Proprotein convertase P-domain
    pfam14843
    Location:634 → 743
    GF_recep_IV; Growth factor receptor domain IV
    pfam16470
    Location:37 → 113
    S8_pro-domain; Peptidase S8 pro-domain

  4. XM_036991293.1 → XP_036847188.1  proprotein convertase subtilisin/kexin type 5 isoform X5

    Conserved Domains (8) summary
    pfam03302
    Location:1263 → 1548
    VSP; Giardia variant-specific surface protein
    cd04059
    Location:125 → 419
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:781 → 822
    FU; Furin-like repeats
    cd00064
    Location:1568 → 1617
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam01483
    Location:504 → 594
    P_proprotein; Proprotein convertase P-domain
    pfam14843
    Location:634 → 743
    GF_recep_IV; Growth factor receptor domain IV
    pfam15913
    Location:1209 → 1277
    Furin-like_2; Furin-like repeat, cysteine-rich
    pfam16470
    Location:37 → 113
    S8_pro-domain; Peptidase S8 pro-domain

  5. XM_036991292.1 → XP_036847187.1  proprotein convertase subtilisin/kexin type 5 isoform X4

    Conserved Domains (8) summary
    pfam03302
    Location:1290 → 1575
    VSP; Giardia variant-specific surface protein
    cd04059
    Location:125 → 419
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:781 → 822
    FU; Furin-like repeats
    cd00064
    Location:1595 → 1644
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:844 → 991
    Furin-like; Furin-like cysteine rich region
    pfam01483
    Location:504 → 594
    P_proprotein; Proprotein convertase P-domain
    pfam14843
    Location:634 → 743
    GF_recep_IV; Growth factor receptor domain IV
    pfam16470
    Location:37 → 113
    S8_pro-domain; Peptidase S8 pro-domain

  6. XM_036991291.1 → XP_036847186.1  proprotein convertase subtilisin/kexin type 5 isoform X3

    Conserved Domains (7) summary
    pfam03302
    Location:1221 → 1506
    VSP; Giardia variant-specific surface protein
    cd04059
    Location:125 → 419
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:1571 → 1615
    FU; Furin-like repeats
    cd00064
    Location:1526 → 1575
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam01483
    Location:504 → 594
    P_proprotein; Proprotein convertase P-domain
    pfam14843
    Location:634 → 743
    GF_recep_IV; Growth factor receptor domain IV
    pfam16470
    Location:37 → 113
    S8_pro-domain; Peptidase S8 pro-domain

  7. XM_017664303.2 → XP_017519792.1  proprotein convertase subtilisin/kexin type 5 isoform X7

Nucleotide Protein
Heading Accession and Version

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