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FGFR2 fibroblast growth factor receptor 2 [ Manis javanica (Malayan pangolin) ]

Gene ID: 108395520, updated on 14-Mar-2024

Summary

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Gene symbol
FGFR2
Gene description
fibroblast growth factor receptor 2
Gene type
protein coding
RefSeq status
MODEL
Organism
Manis javanica
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Pholidota; Manidae; Manis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
19
Annotation release Status Assembly Chr Location
101 current YNU_ManJav_2.0 (GCF_014570535.1) Unplaced Scaffold NW_023435965.1 (23659357..23762812, complement)
100 previous assembly ManJav1.0 (GCF_001685135.1) Unplaced Scaffold NW_016531916.1 (458184..560974, complement)

NW_023435965.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 11 Neighboring gene uncharacterized LOC118971167 Neighboring gene uncharacterized LOC118971176 Neighboring gene arginyltransferase 1 Neighboring gene uncharacterized LOC108392578

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables fibroblast growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables fibroblast growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
fibroblast growth factor receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Manis javanica Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference YNU_ManJav_2.0 Primary Assembly

Genomic

  1. NW_023435965.1 Reference YNU_ManJav_2.0 Primary Assembly

    Range
    23659357..23762812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_037011122.1 → XP_036867017.1  fibroblast growth factor receptor 2 isoform X4

    Conserved Domains (6) summary
    cd05101
    Location:473 → 785
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam18123
    Location:390 → 420
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:50 → 53
    Ig; Ig strand A [structural motif]
    cd05857
    Location:173 → 267
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cd05858
    Location:275 → 379
    IgI_3_FGFR2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:50 → 143
    Ig; Immunoglobulin domain

  2. XM_037011120.1 → XP_036867015.1  fibroblast growth factor receptor 2 isoform X2

    Conserved Domains (6) summary
    cd05101
    Location:475 → 787
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam18123
    Location:390 → 420
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:50 → 53
    Ig; Ig strand A [structural motif]
    cd05857
    Location:173 → 267
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cd05858
    Location:275 → 379
    IgI_3_FGFR2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:50 → 143
    Ig; Immunoglobulin domain

  3. XM_037011121.1 → XP_036867016.1  fibroblast growth factor receptor 2 isoform X3

    Conserved Domains (5) summary
    cd05101
    Location:474 → 786
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam18123
    Location:391 → 421
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:275 → 278
    Ig; Ig strand A [structural motif]
    cd05857
    Location:173 → 267
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:275 → 377
    Ig; Immunoglobulin domain

  4. XM_037011119.1 → XP_036867014.1  fibroblast growth factor receptor 2 isoform X1

    Conserved Domains (5) summary
    cd05101
    Location:476 → 788
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam18123
    Location:391 → 421
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:275 → 278
    Ig; Ig strand A [structural motif]
    cd05857
    Location:173 → 267
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:275 → 377
    Ig; Immunoglobulin domain

  5. XM_037011130.1 → XP_036867025.1  fibroblast growth factor receptor 2 isoform X11

    Conserved Domains (4) summary
    cd05101
    Location:358 → 670
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam18123
    Location:275 → 305
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd05857
    Location:58 → 152
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cd05858
    Location:160 → 264
    IgI_3_FGFR2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); member of the I-set of Ig superfamily (IgSF) domains

  6. XM_037011129.1 → XP_036867024.1  fibroblast growth factor receptor 2 isoform X10

    Conserved Domains (4) summary
    cd05101
    Location:360 → 672
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam18123
    Location:275 → 305
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd05857
    Location:58 → 152
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cd05858
    Location:160 → 264
    IgI_3_FGFR2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); member of the I-set of Ig superfamily (IgSF) domains

  7. XM_037011128.1 → XP_036867023.1  fibroblast growth factor receptor 2 isoform X9

    Conserved Domains (5) summary
    cd05101
    Location:361 → 673
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam18123
    Location:276 → 306
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:160 → 163
    Ig; Ig strand A [structural motif]
    cd05857
    Location:58 → 152
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:160 → 262
    Ig; Immunoglobulin domain

  8. XM_037011127.1 → XP_036867022.1  fibroblast growth factor receptor 2 isoform X8

    Conserved Domains (4) summary
    cd05101
    Location:386 → 698
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam18123
    Location:301 → 331
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd05857
    Location:84 → 178
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cd05858
    Location:186 → 290
    IgI_3_FGFR2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); member of the I-set of Ig superfamily (IgSF) domains

  9. XM_037011125.1 → XP_036867020.1  fibroblast growth factor receptor 2 isoform X7

    Conserved Domains (5) summary
    cd05101
    Location:387 → 699
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam18123
    Location:302 → 332
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:186 → 189
    Ig; Ig strand A [structural motif]
    cd05857
    Location:84 → 178
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:186 → 288
    Ig; Immunoglobulin domain

  10. XM_037011124.1 → XP_036867019.1  fibroblast growth factor receptor 2 isoform X6

    Conserved Domains (6) summary
    cd05101
    Location:473 → 785
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam18123
    Location:390 → 420
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:50 → 53
    Ig; Ig strand A [structural motif]
    cd05857
    Location:173 → 267
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cd05858
    Location:275 → 379
    IgI_3_FGFR2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:50 → 143
    Ig; Immunoglobulin domain

  11. XM_037011123.1 → XP_036867018.1  fibroblast growth factor receptor 2 isoform X5

    Conserved Domains (5) summary
    cd05101
    Location:476 → 788
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam18123
    Location:391 → 421
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:275 → 278
    Ig; Ig strand A [structural motif]
    cd05857
    Location:173 → 267
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:275 → 377
    Ig; Immunoglobulin domain

  12. XM_037011131.1 → XP_036867026.1  fibroblast growth factor receptor 2 isoform X12

    Conserved Domains (4) summary
    cd05101
    Location:386 → 698
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam18123
    Location:301 → 331
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd05857
    Location:84 → 178
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cd05858
    Location:186 → 290
    IgI_3_FGFR2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); member of the I-set of Ig superfamily (IgSF) domains
Nucleotide Protein
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