Slc39a6 solute carrier family 39 (metal ion transporter), member 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc39a6provided by MGI
Official Full Name: solute carrier family 39 (metal ion transporter), member 6provided by MGI
Primary source: MGI:MGI:2147279
See related: Ensembl:ENSMUSG00000024270 AllianceGenome:MGI:2147279
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zip6; Ermelin
Summary: Predicted to enable zinc ion transmembrane transporter activity. Predicted to be involved in cellular zinc ion homeostasis and zinc ion import across plasma membrane. Predicted to act upstream of or within zinc ion transport. Located in endoplasmic reticulum. Is expressed in cerebral cortex ventricular layer; cortical plate; and embryo. Orthologous to human SLC39A6 (solute carrier family 39 member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in whole brain E14.5 (RPKM 19.9), CNS E14 (RPKM 19.7) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 A2; 18 13.18 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (24712938..24736874, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (24579881..24603817, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data demonstrate that LIV-1-GRPEL1 axis dually regulates mitotic exit as well as apoptosis by interacting with PP2A B55alpha and AIF.
Title: The LIV-1-GRPEL1 axis adjusts cell fate during anti-mitotic agent-damaged mitosis.
PrP and ZIP6 inherited the ability to interact with NCAM1 from their common ZIP ancestors but have since diverged to control distinct posttranslational modifications of NCAM1.
Title: A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition.
Zip 6 dysregulation was involved in enhanced inflammation during aging.
Title: Increased inflammatory response in aged mice is associated with age-related zinc deficiency and zinc transporter dysregulation.
mice fed low-Zn diet had reduced number of terminal deoxynucleotidyl transferase dUTP nick end labeling-positive cells compromised seminiferous tubule structure, and reduced Zip10 and Zip6 abundance (>50%; P < 0.5) compared with control diet
Title: Moderate zinc deficiency reduces testicular Zip6 and Zip10 abundance and impairs spermatogenesis in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc39a6 (e-PCR), detects polymorphism
- UniSTS:547107

NoName (e-PCR)
- UniSTS:237750

AI853222 (e-PCR)
- UniSTS:166086

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables monoatomic cation:bicarbonate symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables zinc ion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in epithelial to mesenchymal transition	IDA Inferred from Direct Assay more info	PubMed
involved_in epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in intracellular monoatomic cation homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular zinc ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular zinc ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in lymphocyte activation	ISO Inferred from Sequence Orthology more info
involved_in lymphocyte activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in zinc ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in zinc ion import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in zinc ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in zinc ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium membrane	ISO Inferred from Sequence Orthology more info
located_in lamellipodium membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: zinc transporter ZIP6

Names: ZIP-6; endoplasmic reticulum membrane protein; endoplasmic reticulum membrane-linked protein; solute carrier family 39 member 6; zrt- and Irt-like protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.