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arhgef18b rho/rac guanine nucleotide exchange factor (GEF) 18b [ Austrofundulus limnaeus ]

Gene ID: 106511863, updated on 13-Mar-2024

Summary

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Gene symbol
arhgef18b
Gene description
rho/rac guanine nucleotide exchange factor (GEF) 18b
Gene type
protein coding
RefSeq status
MODEL
Organism
Austrofundulus limnaeus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Austrofundulus
Also known as
arhgef18
Orthologs
human zebrafish all
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Genomic context

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Location:
chromosome: Un
Exon count:
32
Annotation release Status Assembly Chr Location
100 current Austrofundulus_limnaeus-1.0 (GCF_001266775.1) Unplaced Scaffold NW_013952410.1 (3938646..3991486, complement)

NW_013952410.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106511807 Neighboring gene transmembrane serine protease 9 Neighboring gene ectodermal-neural cortex 3 Neighboring gene insulin receptor-like Neighboring gene sphingosine-1-phosphate receptor 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_013952410.1 Unplaced Scaffold Reference Austrofundulus_limnaeus-1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 18
Names
Rho/Rac guanine nucleotide exchange factor 18

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Austrofundulus limnaeus Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Austrofundulus_limnaeus-1.0

Genomic

  1. NW_013952410.1 Reference Austrofundulus_limnaeus-1.0

    Range
    3938646..3991486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014000601.1 → XP_013856055.1  rho guanine nucleotide exchange factor 18 isoform X2

    UniProtKB/TrEMBL
    A0A2I4AKL5
    Conserved Domains (5) summary
    cd00029
    Location:475 → 518
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:685 → 879
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00890
    Location:1335 → 1391
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    cd15794
    Location:921 → 1029
    PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
    pfam00169
    Location:924 → 1025
    PH; PH domain

  2. XM_014000595.1 → XP_013856049.1  rho guanine nucleotide exchange factor 18 isoform X1

    UniProtKB/TrEMBL
    A0A2I4AKM8
    Conserved Domains (5) summary
    cd00029
    Location:490 → 533
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:700 → 894
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00890
    Location:1350 → 1406
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    cd15794
    Location:936 → 1044
    PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
    pfam00169
    Location:939 → 1040
    PH; PH domain
Nucleotide Protein
Heading Accession and Version

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