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MET MET proto-oncogene, receptor tyrosine kinase [ Propithecus coquereli (Coquerel's sifaka) ]

Gene ID: 105817148, updated on 11-Apr-2024

Summary

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Gene symbol
MET
Gene description
MET proto-oncogene, receptor tyrosine kinase
See related
Ensembl:ENSPCOG00000022991
Gene type
protein coding
RefSeq status
MODEL
Organism
Propithecus coquereli
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes; Indriidae; Propithecus
Orthologs
human mouse all
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Genomic context

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See MET in Genome Data Viewer
Location:
chromosome: Un
Exon count:
22
Annotation release Status Assembly Chr Location
100 current Pcoq_1.0 (GCF_000956105.1) Unplaced Scaffold NW_012149729.1 (8031269..8136551, complement)

NW_012149729.1Genomic Context describing neighboring genes Neighboring gene suppression of tumorigenicity 7 Neighboring gene capping actin protein of muscle Z-line subunit alpha 2 Neighboring gene caveolin 1 Neighboring gene caveolin 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_012149729.1 Unplaced Scaffold Reference Pcoq_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables semaphorin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phagocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in semaphorin-plexin signaling pathway involved in axon guidance IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of semaphorin receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
hepatocyte growth factor receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Propithecus coquereli Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Pcoq_1.0 Primary Assembly

Genomic

  1. NW_012149729.1 Reference Pcoq_1.0 Primary Assembly

    Range
    8031269..8136551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012652779.1 → XP_012508233.1  hepatocyte growth factor receptor isoform X2

    UniProtKB/TrEMBL
    A0A2K6G6M6
    Related
    ENSPCOP00000021885.1, ENSPCOT00000032555.1
    Conserved Domains (8) summary
    cd11278
    Location:25 → 517
    Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
    smart00429
    Location:839 → 935
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:658 → 741
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:564 → 657
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd05058
    Location:1083 → 1344
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    pfam01437
    Location:520 → 562
    PSI; Plexin repeat
    pfam07714
    Location:1079 → 1338
    Pkinase_Tyr; Protein tyrosine kinase
    cl15674
    Location:743 → 838
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  2. XM_012652780.1 → XP_012508234.1  hepatocyte growth factor receptor isoform X3

    UniProtKB/TrEMBL
    A0A2K6G6M6
    Conserved Domains (8) summary
    cd11278
    Location:44 → 536
    Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
    smart00429
    Location:858 → 954
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:677 → 760
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:583 → 676
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd05058
    Location:1055 → 1316
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    pfam01437
    Location:539 → 581
    PSI; Plexin repeat
    pfam07714
    Location:1051 → 1310
    Pkinase_Tyr; Protein tyrosine kinase
    cl15674
    Location:762 → 857
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  3. XM_012652778.1 → XP_012508232.1  hepatocyte growth factor receptor isoform X1

    UniProtKB/TrEMBL
    A0A2K6G6M6
    Conserved Domains (8) summary
    cd11278
    Location:44 → 536
    Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
    smart00429
    Location:858 → 954
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:677 → 760
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:583 → 676
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd05058
    Location:1102 → 1363
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    pfam01437
    Location:539 → 581
    PSI; Plexin repeat
    pfam07714
    Location:1098 → 1357
    Pkinase_Tyr; Protein tyrosine kinase
    cl15674
    Location:762 → 857
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
Nucleotide Protein
Heading Accession and Version

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