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SETDB2 SET domain bifurcated histone lysine methyltransferase 2 [ Cercocebus atys (sooty mangabey) ]

Gene ID: 105587753, updated on 13-Mar-2024

Summary

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Gene symbol
SETDB2
Gene description
SET domain bifurcated histone lysine methyltransferase 2
See related
Ensembl:ENSCATG00000002055
Gene type
protein coding
RefSeq status
MODEL
Organism
Cercocebus atys
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Cercocebus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
20
Annotation release Status Assembly Chr Location
100 current Caty_1.0 (GCF_000955945.1) Unplaced Scaffold NW_012000853.1 (2759237..2810823, complement)

NW_012000853.1Genomic Context describing neighboring genes Neighboring gene RCC1 and BTB domain containing protein 1 Neighboring gene PHD finger protein 11 Neighboring gene calcium binding protein 39 like Neighboring gene tigger transposable element-derived protein 1-like Neighboring gene cytidine and dCMP deaminase domain containing 1 Neighboring gene prolyl 3-hydroxylase OGFOD1 pseudogene

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_012000853.1 Unplaced Scaffold Reference Caty_1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histone H3K9 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in heterochromatin organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of DNA methylation-dependent heterochromatin formation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone-lysine N-methyltransferase SETDB2
Names
SET domain bifurcated 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cercocebus atys Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Caty_1.0

Genomic

  1. NW_012000853.1 Reference Caty_1.0

    Range
    2759237..2810823 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012064276.1 → XP_011919666.1  histone-lysine N-methyltransferase SETDB2 isoform X1

    See identical proteins and their annotated locations for XP_011919666.1

    UniProtKB/TrEMBL
    A0A2K5KIX2
    Conserved Domains (3) summary
    smart00317
    Location:669 → 735
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd01395
    Location:203 → 263
    HMT_MBD; Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated ...
    pfam05033
    Location:285 → 398
    Pre-SET; Pre-SET motif

  2. XM_012064275.1 → XP_011919665.1  histone-lysine N-methyltransferase SETDB2 isoform X1

    See identical proteins and their annotated locations for XP_011919665.1

    UniProtKB/TrEMBL
    A0A2K5KIX2
    Conserved Domains (3) summary
    smart00317
    Location:669 → 735
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd01395
    Location:203 → 263
    HMT_MBD; Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated ...
    pfam05033
    Location:285 → 398
    Pre-SET; Pre-SET motif

  3. XM_012064278.1 → XP_011919668.1  histone-lysine N-methyltransferase SETDB2 isoform X3

    UniProtKB/TrEMBL
    A0A2K5KIX2, A0A2K5KIX4
    Related
    ENSCATP00000000630.1, ENSCATT00000003476.1
    Conserved Domains (3) summary
    smart00317
    Location:630 → 696
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd01395
    Location:164 → 224
    HMT_MBD; Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated ...
    pfam05033
    Location:246 → 359
    Pre-SET; Pre-SET motif

  4. XM_012064279.1 → XP_011919669.1  histone-lysine N-methyltransferase SETDB2 isoform X4

    UniProtKB/TrEMBL
    A0A2K5KIU5
    Related
    ENSCATP00000000613.1, ENSCATT00000003369.1
    Conserved Domains (3) summary
    smart00317
    Location:628 → 694
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam05033
    Location:244 → 357
    Pre-SET; Pre-SET motif
    cl00110
    Location:203 → 227
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...

  5. XM_012064273.1 → XP_011919663.1  histone-lysine N-methyltransferase SETDB2 isoform X1

    See identical proteins and their annotated locations for XP_011919663.1

    UniProtKB/TrEMBL
    A0A2K5KIX2
    Conserved Domains (3) summary
    smart00317
    Location:669 → 735
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd01395
    Location:203 → 263
    HMT_MBD; Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated ...
    pfam05033
    Location:285 → 398
    Pre-SET; Pre-SET motif

  6. XM_012064280.1 → XP_011919670.1  histone-lysine N-methyltransferase SETDB2 isoform X5

    UniProtKB/TrEMBL
    A0A2K5KIU0
    Conserved Domains (3) summary
    smart00317
    Location:515 → 581
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd01395
    Location:49 → 109
    HMT_MBD; Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated ...
    pfam05033
    Location:131 → 244
    Pre-SET; Pre-SET motif

  7. XM_012064277.1 → XP_011919667.1  histone-lysine N-methyltransferase SETDB2 isoform X2

    UniProtKB/TrEMBL
    A0A2K5KIX2
    Conserved Domains (3) summary
    smart00317
    Location:406 → 467
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd01395
    Location:203 → 263
    HMT_MBD; Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated ...
    pfam05033
    Location:285 → 398
    Pre-SET; Pre-SET motif
Nucleotide Protein
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