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NGEF neuronal guanine nucleotide exchange factor [ Camelus dromedarius (Arabian camel) ]

Gene ID: 105105238, updated on 19-Apr-2024

Summary

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Gene symbol
NGEF
Gene description
neuronal guanine nucleotide exchange factor
Locus tag
Cadr_000007540
Gene type
protein coding
RefSeq status
MODEL
Organism
Camelus dromedarius
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus
Also known as
Ephexin-1
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_04 current mCamDro1.pat (GCF_036321535.1) 4 NC_087439.1 (92115074..92216430, complement)
101 previous assembly CamDro3 (GCF_000803125.2) 5 NC_044515.1 (90974854..91076155, complement)

Chromosome 4 - NC_087439.1Genomic Context describing neighboring genes Neighboring gene GRB10 interacting GYF protein 2 Neighboring gene potassium inwardly rectifying channel subfamily J member 13 Neighboring gene uncharacterized LOC135321172 Neighboring gene secondary ossification center associated regulator of chondrocyte maturation Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene GTP-binding protein SAR1b-like Neighboring gene neuraminidase 2 Neighboring gene inositol polyphosphate-5-phosphatase D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ephexin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036321535.1-RS_2024_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mCamDro1.pat

Genomic

  1. NC_087439.1 Reference mCamDro1.pat

    Range
    92115074..92216430 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010999013.3 → XP_010997315.2  ephexin-1 isoform X1

    UniProtKB/TrEMBL
    A0A5N4E7F2
    Conserved Domains (3) summary
    cd11939
    Location:609 → 663
    SH3_ephexin1; Src homology 3 domain of the Rho guanine nucleotide exchange factor, ephexin-1 (also called NGEF or ARHGEF27)
    cd01221
    Location:470 → 596
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:270 → 448
    RhoGEF; RhoGEF domain

  2. XM_031452429.2 → XP_031308289.1  ephexin-1 isoform X3

    UniProtKB/TrEMBL
    A0A5N4E7F2
    Conserved Domains (3) summary
    cd11939
    Location:457 → 511
    SH3_ephexin1; Src homology 3 domain of the Rho guanine nucleotide exchange factor, ephexin-1 (also called NGEF or ARHGEF27)
    cd01221
    Location:318 → 444
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:118 → 296
    RhoGEF; RhoGEF domain

  3. XM_031452428.2 → XP_031308288.1  ephexin-1 isoform X2

    UniProtKB/TrEMBL
    A0A5N4E7F2
    Conserved Domains (3) summary
    cd11939
    Location:523 → 577
    SH3_ephexin1; Src homology 3 domain of the Rho guanine nucleotide exchange factor, ephexin-1 (also called NGEF or ARHGEF27)
    cd01221
    Location:384 → 510
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:184 → 362
    RhoGEF; RhoGEF domain
Nucleotide Protein
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