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kalrna kalirin RhoGEF kinase a [ Esox lucius (northern pike) ]

Gene ID: 105016154, updated on 18-Jun-2024

Summary

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Gene symbol
kalrna
Gene description
kalirin RhoGEF kinase a
See related
Ensembl:ENSELUG00000014491
Gene type
protein coding
RefSeq status
MODEL
Organism
Esox lucius
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes; Esocidae; Esox
Also known as
kalrn
Orthologs
zebrafish all
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Genomic context

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Location:
chromosome: 16
Exon count:
64
Annotation release Status Assembly Chr Location
104 current fEsoLuc1.pri (GCF_011004845.1) 16 NC_047584.1 (20047946..20223622, complement)
103 previous assembly Eluc_v4 (GCF_004634155.1) Linkage Group LG16 NC_025983.4 (14486246..14658974)

Chromosome 16 - NC_047584.1Genomic Context describing neighboring genes Neighboring gene crystallin, beta A2b Neighboring gene uridine monophosphate synthetase Neighboring gene myosin, light chain kinase a Neighboring gene WD repeat domain 75 Neighboring gene solute carrier family 40 member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The genome and linkage map of the northern pike (Esox lucius): conserved synteny revealed between the salmonid sister group and the Neoteleostei. Rondeau EB, et al. PLoS One, 2014. PMID 25069045, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
kalirin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Esox lucius Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference fEsoLuc1.pri Primary Assembly

Genomic

  1. NC_047584.1 Reference fEsoLuc1.pri Primary Assembly

    Range
    20047946..20223622 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_020054882.3 → XP_019910441.3  kalirin isoform X3

    UniProtKB/TrEMBL
    A0A3P9A3H1
    Related
    ENSELUP00000052605.2, ENSELUT00000077548.2
    Conserved Domains (14) summary
    smart00150
    Location:1122 → 1222
    SPEC; Spectrin repeats
    cd11852
    Location:1637 → 1696
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2313 → 2371
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:39 → 177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2537 → 2629
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1272 → 1442
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:537 → 753
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1449 → 1571
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2094 → 2228
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:1920 → 2089
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1694 → 1919
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2450 → 2453
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:2442 → 2533
    Ig; Immunoglobulin domain
    cl21453
    Location:2658 → 2905
    PKc_like; Protein Kinases, catalytic domain

  2. XM_010879791.5 → XP_010878093.4  kalirin isoform X1

    UniProtKB/TrEMBL
    A0A3P9A3H1
    Conserved Domains (14) summary
    smart00150
    Location:1122 → 1222
    SPEC; Spectrin repeats
    cd11852
    Location:1637 → 1696
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2313 → 2371
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:39 → 177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2557 → 2649
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1272 → 1442
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:537 → 753
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1449 → 1571
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2094 → 2228
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:1920 → 2089
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1694 → 1919
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2470 → 2473
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:2462 → 2553
    Ig; Immunoglobulin domain
    cl21453
    Location:2678 → 2925
    PKc_like; Protein Kinases, catalytic domain

  3. XM_020054883.3 → XP_019910442.3  kalirin isoform X4

    UniProtKB/TrEMBL
    A0A3P9A3C6
    Related
    ENSELUP00000035256.3, ENSELUT00000022781.3
    Conserved Domains (14) summary
    smart00150
    Location:1122 → 1222
    SPEC; Spectrin repeats
    cd11852
    Location:1637 → 1696
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2281 → 2339
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:39 → 177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2525 → 2617
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1272 → 1442
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:537 → 753
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1449 → 1571
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2062 → 2196
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:1888 → 2057
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1694 → 1846
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2438 → 2441
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:2430 → 2521
    Ig; Immunoglobulin domain
    cl21453
    Location:2646 → 2893
    PKc_like; Protein Kinases, catalytic domain

  4. XM_020054881.3 → XP_019910440.3  kalirin isoform X2

    UniProtKB/TrEMBL
    A0A3P9A3H1
    Related
    ENSELUP00000035255.3, ENSELUT00000022740.3
    Conserved Domains (14) summary
    smart00150
    Location:1122 → 1222
    SPEC; Spectrin repeats
    cd11852
    Location:1637 → 1696
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2312 → 2370
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:39 → 177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2556 → 2648
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1272 → 1442
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:537 → 753
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1449 → 1571
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2094 → 2228
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:1920 → 2089
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1694 → 1919
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2469 → 2472
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:2461 → 2552
    Ig; Immunoglobulin domain
    cl21453
    Location:2677 → 2924
    PKc_like; Protein Kinases, catalytic domain

  5. XM_020054885.2 → XP_019910444.2  kalirin isoform X6

    Conserved Domains (9) summary
    cd11852
    Location:30 → 89
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:706 → 764
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00325
    Location:313 → 483
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00063
    Location:950 → 1042
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd13241
    Location:487 → 621
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam16609
    Location:87 → 312
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:863 → 866
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:855 → 946
    Ig; Immunoglobulin domain
    cl21453
    Location:1071 → 1318
    PKc_like; Protein Kinases, catalytic domain

  6. XM_020054886.2 → XP_019910445.2  kalirin isoform X7

    Conserved Domains (9) summary
    cd11852
    Location:21 → 80
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:697 → 755
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00325
    Location:304 → 474
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00063
    Location:941 → 1033
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd13241
    Location:478 → 612
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam16609
    Location:78 → 303
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:854 → 857
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:846 → 937
    Ig; Immunoglobulin domain
    cl21453
    Location:1062 → 1309
    PKc_like; Protein Kinases, catalytic domain

  7. XM_020054884.2 → XP_019910443.2  kalirin isoform X5

    Conserved Domains (9) summary
    cd11852
    Location:51 → 110
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:727 → 785
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00325
    Location:334 → 504
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00063
    Location:971 → 1063
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd13241
    Location:508 → 642
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam16609
    Location:108 → 333
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:884 → 887
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:876 → 967
    Ig; Immunoglobulin domain
    cl21453
    Location:1092 → 1339
    PKc_like; Protein Kinases, catalytic domain

  8. XM_020054887.2 → XP_019910446.2  kalirin isoform X8

    Conserved Domains (8) summary
    cd11853
    Location:626 → 684
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00325
    Location:233 → 403
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00063
    Location:870 → 962
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd13241
    Location:407 → 541
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam16609
    Location:27 → 232
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:783 → 786
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:775 → 866
    Ig; Immunoglobulin domain
    cl21453
    Location:991 → 1238
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
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