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Alas1 5'-aminolevulinate synthase 1 [ Fukomys damarensis (Damara mole-rat) ]

Gene ID: 104863124, updated on 12-Mar-2024

Summary

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Gene symbol
Alas1
Gene description
5'-aminolevulinate synthase 1
Locus tag
H920_05859
See related
Ensembl:ENSFDAG00000017931
Gene type
protein coding
RefSeq status
MODEL
Organism
Fukomys damarensis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Fukomys
Orthologs
human mouse all
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Genomic context

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See Alas1 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
12
Annotation release Status Assembly Chr Location
102 current DMR_v1.0_HiC (GCF_012274545.1) Unplaced Scaffold NW_022900949.1 (43667811..43682641)
101 previous assembly DMR_v1.0 (GCF_000743615.1) Unplaced Scaffold NW_011044745.1 (1087423..1102255)

NW_022900949.1Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 7 Neighboring gene POC1 centriolar protein A Neighboring gene volume-regulated anion channel subunit LRRC8B-like Neighboring gene twinfilin-2 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1M

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 5-aminolevulinate synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in erythrocyte development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hemoglobin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
5-aminolevulinate synthase, nonspecific, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Fukomys damarensis Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference DMR_v1.0_HiC Primary Assembly

Genomic

  1. NW_022900949.1 Reference DMR_v1.0_HiC Primary Assembly

    Range
    43667811..43682641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010625427.3 → XP_010623729.1  5-aminolevulinate synthase, nonspecific, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_010623729.1

    Related
    ENSFDAP00000010091.1
    Conserved Domains (3) summary
    COG0156
    Location:197 → 588
    BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]
    pfam09029
    Location:2 → 138
    Preseq_ALAS; 5-aminolevulinate synthase presequence
    cl18945
    Location:197 → 602
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

  2. XM_010625428.2 → XP_010623730.1  5-aminolevulinate synthase, nonspecific, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_010623730.1

    Conserved Domains (3) summary
    COG0156
    Location:197 → 588
    BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]
    pfam09029
    Location:2 → 138
    Preseq_ALAS; 5-aminolevulinate synthase presequence
    cl18945
    Location:197 → 602
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

  3. XM_010625429.3 → XP_010623731.1  5-aminolevulinate synthase, nonspecific, mitochondrial isoform X2

    Conserved Domains (3) summary
    COG0156
    Location:83 → 474
    BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]
    pfam09029
    Location:1 → 24
    Preseq_ALAS; 5-aminolevulinate synthase presequence
    cl18945
    Location:83 → 488
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
Nucleotide Protein
Heading Accession and Version

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