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ITCH itchy E3 ubiquitin protein ligase [ Chlamydotis macqueenii (Macqueen's bustard) ]

Gene ID: 104475811, updated on 3-Aug-2024

Summary

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Gene symbol
ITCH
Gene description
itchy E3 ubiquitin protein ligase
Locus tag
N324_04721
Gene type
protein coding
RefSeq status
MODEL
Organism
Chlamydotis macqueenii
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Neoaves; Otidimorphae; Otidiformes; Otididae; Chlamydotis
Orthologs
human mouse all
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Genomic context

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See ITCH in Genome Data Viewer
Location:
chromosome: Un
Exon count:
23
Annotation release Status Assembly Chr Location
100 current ASM69519v1 (GCF_000695195.1) Unplaced Scaffold NW_010461381.1 (5043..37779, complement)

NW_010461381.1Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_010461381.1 Unplaced Scaffold Reference ASM69519v1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein K29-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein K48-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein K63-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase Itchy homolog
Names
E3 ubiquitin-protein ligase Itchy

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Chlamydotis macqueenii Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM69519v1

Genomic

  1. NW_010461381.1 Reference ASM69519v1

    Range
    5043..37779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010115387.1 → XP_010113689.1  E3 ubiquitin-protein ligase Itchy homolog isoform X2

    UniProtKB/TrEMBL
    A0A091KG95
    Conserved Domains (5) summary
    cd04021
    Location:17 → 139
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    smart00456
    Location:444 → 475
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:537 → 865
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:513 → 866
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:405 → 434
    WW; WW domain

  2. XM_010115386.1 → XP_010113688.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    UniProtKB/TrEMBL
    A0A091KG95
    Conserved Domains (5) summary
    cd04021
    Location:17 → 139
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    smart00456
    Location:455 → 486
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:548 → 876
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:524 → 877
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:416 → 445
    WW; WW domain
Nucleotide Protein
Heading Accession and Version

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