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0610010K14Rik RIKEN cDNA 0610010K14 gene [ Mus musculus (house mouse) ]

Gene ID: 104457, updated on 30-Apr-2024

Summary

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Official Symbol
0610010K14Rikprovided by MGI
Official Full Name
RIKEN cDNA 0610010K14 geneprovided by MGI
Primary source
MGI:MGI:1915609
See related
Ensembl:ENSMUSG00000020831 AllianceGenome:MGI:1915609
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bap18; 1110020A23Rik
Summary
Predicted to enable identical protein binding activity. Predicted to act upstream of or within chromatin organization. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of MLL1 complex and NURF complex. Is expressed in several structures, including alimentary system; eye; genitourinary system; leg; and nervous system. Orthologous to human C17orf49 (chromosome 17 open reading frame 49). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 52.3), CNS E14 (RPKM 43.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See 0610010K14Rik in Genome Data Viewer
Location:
11 B3; 11 42.99 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70126030..70128808, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70235204..70237923, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene microRNA 497b Neighboring gene microRNA 195a Neighboring gene microRNA 497 Neighboring gene STARR-positive B cell enhancer ABC_E1832 Neighboring gene STARR-positive B cell enhancer ABC_E2998 Neighboring gene ribonuclease, RNase K Neighboring gene predicted gene, 40191 Neighboring gene arachidonate 12-lipoxygenase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. Gagliardi A, et al. EMBO J, 2013 Aug 14. PMID 23892456, Free PMC Article
  2. An Oct4-centered protein interaction network in embryonic stem cells. van den Berg DLC, et al. Cell Stem Cell, 2010 Apr 2. PMID 20362541, Free PMC Article
  3. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288, Free PMC Article
  4. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
  5. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of MLL1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of NURF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NURF complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
chromatin complexes subunit BAP18
Names
BPTF-associated protein of 18 kDa
MLL1/MLL complex subunit C17orf49 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177601.1 → NP_001171072.1  chromatin complexes subunit BAP18 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AA189586, AK003842, CK791552, EL959640
    Consensus CDS
    CCDS48834.1
    UniProtKB/TrEMBL
    D3Z687
    Related
    ENSMUSP00000104216.4, ENSMUST00000108576.10
    Conserved Domains (2) summary
    smart00717
    Location:41 → 77
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:41 → 77
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  2. NM_001177603.1 → NP_001171074.1  chromatin complexes subunit BAP18 isoform 3

    See identical proteins and their annotated locations for NP_001171074.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate, in-frame exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AA189586, AW557771, CB192659
    Consensus CDS
    CCDS48833.1
    UniProtKB/TrEMBL
    F6XN97
    Related
    ENSMUSP00000021181.7, ENSMUST00000021181.13
    Conserved Domains (2) summary
    smart00717
    Location:41 → 77
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:41 → 77
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  3. NM_001177606.1 → NP_001171077.1  chromatin complexes subunit BAP18 isoform 5

    See identical proteins and their annotated locations for NP_001171077.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two alternate, in-frame exons, compared to variant 1. The resulting protein (isoform 5) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AA189586, AK003842, AK169173
    Consensus CDS
    CCDS48832.1
    UniProtKB/TrEMBL
    A2CF80
    Related
    ENSMUSP00000104220.2, ENSMUST00000108579.8

  4. NM_001177607.1 → NP_001171078.1  chromatin complexes subunit BAP18 isoform 6

    See identical proteins and their annotated locations for NP_001171078.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two alternate, in-frame exons and uses a different splice site in the 3' UTR, compared to variant 1. The resulting protein (isoform 6) has a shorter and distinct C-terminue when it is compared to isoform 1.
    Source sequence(s)
    AA189586, AK003842, BE861439
    Consensus CDS
    CCDS48831.1
    UniProtKB/TrEMBL
    A2CF80, A2CF83
    Related
    ENSMUSP00000104215.3, ENSMUST00000108575.9

  5. NM_026757.2 → NP_081033.1  chromatin complexes subunit BAP18 isoform 4

    See identical proteins and their annotated locations for NP_081033.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate, in-frame exon in the 5' coding region and uses a different splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 4) is shorter and has a distinct C-terminus when compared to isoform 1.
    Source sequence(s)
    AA189586, AK003842
    Consensus CDS
    CCDS24940.1
    UniProtKB/Swiss-Prot
    Q9DCT6
    Related
    ENSMUSP00000099629.4, ENSMUST00000102569.10

  6. NM_145758.1 → NP_665701.1  chromatin complexes subunit BAP18 isoform 2

    See identical proteins and their annotated locations for NP_665701.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AA189586, AK002491, AK003842
    Consensus CDS
    CCDS48835.1
    UniProtKB/Swiss-Prot
    Q3TFE6, Q7TMP3, Q9D183, Q9DCT6
    UniProtKB/TrEMBL
    F6XN97
    Related
    ENSMUSP00000104219.3, ENSMUST00000108578.9
    Conserved Domains (2) summary
    smart00717
    Location:41 → 77
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:41 → 77
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    70126030..70128808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245456.2 → XP_030101316.1  chromatin complexes subunit BAP18 isoform X2

    UniProtKB/TrEMBL
    A2CF80, A2CF83

  2. XM_017314213.3 → XP_017169702.1  chromatin complexes subunit BAP18 isoform X1

RNA

  1. XR_003949208.2 RNA Sequence

  2. XR_003949207.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DCT6.1 GenPept UniProtKB/Swiss-Prot:Q9DCT6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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