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Sppl2b signal peptide peptidase like 2B [ Nannospalax galili (Upper Galilee mountains blind mole rat) ]

Gene ID: 103737291, updated on 11-Mar-2024

Summary

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Gene symbol
Sppl2b
Gene description
signal peptide peptidase like 2B
See related
Ensembl:ENSNGAG00000004736
Gene type
protein coding
RefSeq status
MODEL
Organism
Nannospalax galili
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Spalacidae; Spalacinae; Nannospalax
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
15
Annotation release Status Assembly Chr Location
102 current S.galili_v1.0 (GCF_000622305.1) Unplaced Scaffold NW_008341457.1 (2651510..2665747, complement)

NW_008341457.1Genomic Context describing neighboring genes Neighboring gene transmembrane serine protease 9 Neighboring gene long-chain fatty acid transport protein 4 pseudogene Neighboring gene LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene leucine rich repeat and Ig domain containing 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_008341457 Unplaced Scaffold Reference S.galili_v1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables aspartic endopeptidase activity, intramembrane cleaving IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in membrane protein proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi-associated vesicle membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasmic side of endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lumenal side of endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
signal peptide peptidase-like 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Nannospalax galili Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference S.galili_v1.0 Primary Assembly

Genomic

  1. NW_008341457.1 Reference S.galili_v1.0 Primary Assembly

    Range
    2651510..2665747 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008837099.3 → XP_008835321.1  signal peptide peptidase-like 2B isoform X7

    UniProtKB/TrEMBL
    A0A8C6QHQ3
    Conserved Domains (3) summary
    PHA03247
    Location:429 → 522
    PHA03247; large tegument protein UL36; Provisional
    pfam04258
    Location:146 → 438
    Peptidase_A22B; Signal peptide peptidase
    cl28883
    Location:38 → 96
    PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...

  2. XM_008837098.3 → XP_008835320.1  signal peptide peptidase-like 2B isoform X4

    UniProtKB/TrEMBL
    A0A8C6QHQ3
    Conserved Domains (3) summary
    PHA03247
    Location:502 → 581
    PHA03247; large tegument protein UL36; Provisional
    cd02129
    Location:38 → 157
    PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
    pfam04258
    Location:206 → 498
    Peptidase_A22B; Signal peptide peptidase

  3. XM_008837096.3 → XP_008835318.1  signal peptide peptidase-like 2B isoform X2

    UniProtKB/TrEMBL
    A0A8C6QHQ3
    Conserved Domains (3) summary
    PHA03247
    Location:489 → 582
    PHA03247; large tegument protein UL36; Provisional
    cd02129
    Location:38 → 157
    PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
    pfam04258
    Location:206 → 498
    Peptidase_A22B; Signal peptide peptidase

  4. XM_017799150.2 → XP_017654639.1  signal peptide peptidase-like 2B isoform X5

    UniProtKB/TrEMBL
    A0A8C6QHQ3
    Conserved Domains (3) summary
    PHA03247
    Location:465 → 558
    PHA03247; large tegument protein UL36; Provisional
    cd02129
    Location:38 → 157
    PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
    pfam04258
    Location:207 → 474
    Peptidase_A22B; Signal peptide peptidase

  5. XM_008837097.3 → XP_008835319.1  signal peptide peptidase-like 2B isoform X3

    UniProtKB/TrEMBL
    A0A8C6QHQ3
    Conserved Domains (3) summary
    PHA03247
    Location:503 → 582
    PHA03247; large tegument protein UL36; Provisional
    cd02129
    Location:38 → 157
    PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
    pfam04258
    Location:207 → 499
    Peptidase_A22B; Signal peptide peptidase

  6. XM_008837095.3 → XP_008835317.1  signal peptide peptidase-like 2B isoform X1

    UniProtKB/TrEMBL
    A0A8C6QHQ3
    Conserved Domains (3) summary
    PHA03247
    Location:490 → 583
    PHA03247; large tegument protein UL36; Provisional
    cd02129
    Location:38 → 157
    PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
    pfam04258
    Location:207 → 499
    Peptidase_A22B; Signal peptide peptidase

  7. XM_029565405.1 → XP_029421265.1  signal peptide peptidase-like 2B isoform X6

    UniProtKB/TrEMBL
    A0A8C6QHQ3
    Related
    ENSNGAP00000003938.1, ENSNGAT00000006047.1
    Conserved Domains (2) summary
    cd02129
    Location:38 → 157
    PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
    pfam04258
    Location:207 → 499
    Peptidase_A22B; Signal peptide peptidase

  8. XM_008837100.3 → XP_008835322.1  signal peptide peptidase-like 2B isoform X8

    UniProtKB/TrEMBL
    A0A8C6QHQ3
    Conserved Domains (2) summary
    cd02129
    Location:38 → 157
    PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
    pfam04258
    Location:207 → 499
    Peptidase_A22B; Signal peptide peptidase

  9. XM_029565407.1 → XP_029421267.1  signal peptide peptidase-like 2B isoform X8

    UniProtKB/TrEMBL
    A0A8C6QHQ3
    Conserved Domains (2) summary
    cd02129
    Location:38 → 157
    PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
    pfam04258
    Location:207 → 499
    Peptidase_A22B; Signal peptide peptidase

  10. XM_029565406.1 → XP_029421266.1  signal peptide peptidase-like 2B isoform X8

    UniProtKB/TrEMBL
    A0A8C6QHQ3
    Conserved Domains (2) summary
    cd02129
    Location:38 → 157
    PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...
    pfam04258
    Location:207 → 499
    Peptidase_A22B; Signal peptide peptidase
Nucleotide Protein
Heading Accession and Version

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