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BACE1 beta-secretase 1 [ Ursus maritimus (polar bear) ]

Gene ID: 103662352, updated on 11-Mar-2024

Summary

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Gene symbol
BACE1
Gene description
beta-secretase 1
See related
Ensembl:ENSUMAG00000002549
Gene type
protein coding
RefSeq status
MODEL
Organism
Ursus maritimus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
11
Annotation release Status Assembly Chr Location
101 current ASM1731132v1 (GCF_017311325.1) Unplaced Scaffold NW_024424008.1 (50229126..50281481)
100 previous assembly UrsMar_1.0 (GCF_000687225.1) Unplaced Scaffold NW_007907111.1 (5640662..5692688)

NW_024424008.1Genomic Context describing neighboring genes Neighboring gene centrosomal protein 164 Neighboring gene small nuclear ribonucleoprotein-associated protein N-like Neighboring gene SNRPN upstream reading frame protein-like Neighboring gene ring finger protein 214 Neighboring gene proprotein convertase subtilisin/kexin type 7 Neighboring gene transgelin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in amyloid-beta metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
beta-secretase 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Ursus maritimus Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM1731132v1 Primary Assembly

Genomic

  1. NW_024424008.1 Reference ASM1731132v1 Primary Assembly

    Range
    50229126..50281481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008690032.2 → XP_008688254.1  beta-secretase 1 isoform X3

    UniProtKB/TrEMBL
    A0A384C1E2
    Related
    ENSUMAP00000002912.1
    Conserved Domains (1) summary
    cd05473
    Location:72 → 424
    beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease

  2. XM_008690030.2 → XP_008688252.1  beta-secretase 1 isoform X1

    UniProtKB/TrEMBL
    A0A384C083
    Conserved Domains (1) summary
    cd05473
    Location:72 → 423
    beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease

  3. XM_008690033.2 → XP_008688255.1  beta-secretase 1 isoform X4

    UniProtKB/TrEMBL
    A0A384C1G6
    Conserved Domains (1) summary
    cl11403
    Location:88 → 321
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

  4. XM_008690031.2 → XP_008688253.1  beta-secretase 1 isoform X2

    UniProtKB/TrEMBL
    A0A384C079
    Related
    ENSUMAP00000002915.1
    Conserved Domains (1) summary
    cd05473
    Location:72 → 437
    beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease
Nucleotide Protein
Heading Accession and Version

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