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PSEN2 presenilin 2 [ Eptesicus fuscus (big brown bat) ]

Gene ID: 103301080, updated on 30-Mar-2024

Summary

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Gene symbol
PSEN2
Gene description
presenilin 2
Gene type
protein coding
RefSeq status
MODEL
Organism
Eptesicus fuscus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Chiroptera; Yangochiroptera; Vespertilionidae; Eptesicus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 24
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_03 current DD_ASM_mEF_20220401 (GCF_027574615.1) 24 NC_072496.1 (15827492..15848630, complement)
101 previous assembly EptFus1.0 (GCF_000308155.1) Unplaced Scaffold NW_007370830.1 (1854140..1875099, complement)

Chromosome 24 - NC_072496.1Genomic Context describing neighboring genes Neighboring gene CDC42 binding protein kinase alpha Neighboring gene tRNA (guanine(26)-N(2))-dimethyltransferase-like Neighboring gene coenzyme Q8A Neighboring gene inositol-trisphosphate 3-kinase B Neighboring gene stum, mechanosensory transduction mediator homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables aspartic endopeptidase activity, intramembrane cleaving IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch receptor processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in amyloid precursor protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in amyloid-beta metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in ciliary rootlet IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in dendritic shaft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
presenilin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_027574615.1-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference DD_ASM_mEF_20220401

Genomic

  1. NC_072496.1 Reference DD_ASM_mEF_20220401

    Range
    15827492..15848630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054713034.1 → XP_054569009.1  presenilin-2 isoform X2

  2. XM_054713033.1 → XP_054569008.1  presenilin-2 isoform X1

Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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