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tjp2a tight junction protein 2a (zona occludens 2) [ Callorhinchus milii (elephant shark) ]

Gene ID: 103178109, updated on 11-Mar-2024

Summary

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Gene symbol
tjp2a
Gene description
tight junction protein 2a (zona occludens 2)
See related
Ensembl:ENSCMIG00000010132
Gene type
protein coding
RefSeq status
MODEL
Organism
Callorhinchus milii
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes; Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus
Also known as
tjp2
Orthologs
zebrafish all
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Genomic context

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Location:
chromosome: Un
Exon count:
27
Annotation release Status Assembly Chr Location
101 current IMCB_Cmil_1.0 (GCF_018977255.1) Unplaced Scaffold NW_024704742.1 (86770579..86858208, complement)
100 previous assembly Callorhinchus_milii-6.1.3 (GCF_000165045.1) Unplaced Scaffold NW_006890077.1 (7991940..8080671)

NW_024704742.1Genomic Context describing neighboring genes Neighboring gene transfer RNA valine (anticodon UAC) Neighboring gene family with sequence similarity 189 member A2 Neighboring gene beta-crystallin B1-like Neighboring gene frataxin Neighboring gene phosphatidylinositol-4-phosphate 5-kinase, type I, beta b Neighboring gene transfer RNA threonine (anticodon UGU)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequencing and analysis of full-length cDNAs, 5'-ESTs and 3'-ESTs from a cartilaginous fish, the elephant shark (Callorhinchus milii). Tan YY, et al. PLoS One, 2012. PMID 23056606, Free PMC Article
  2. Elephant shark genome provides unique insights into gnathostome evolution. Venkatesh B, et al. Nature, 2014 Jan 9. PMID 24402279, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-cell junction organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in establishment of endothelial intestinal barrier IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of blood-brain barrier permeability IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein localization to cell-cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tight junction protein ZO-2a
Names
tight junction protein 2
tight junction protein ZO-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Callorhinchus milii Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference IMCB_Cmil_1.0 Primary Assembly

Genomic

  1. NW_024704742.1 Reference IMCB_Cmil_1.0 Primary Assembly

    Range
    86770579..86858208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_007892654.2 → XP_007890845.1  tight junction protein ZO-2a isoform X3

    See identical proteins and their annotated locations for XP_007890845.1

    UniProtKB/TrEMBL
    A0A4W3I2J6, A0A4W3I740
    Conserved Domains (5) summary
    smart00072
    Location:634 → 809
    GuKc; Guanylate kinase homologues
    smart00228
    Location:242 → 313
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam17069
    Location:124 → 223
    RSRP; Arginine/Serine-Rich protein 1
    cl17036
    Location:534 → 600
    SH3; Src Homology 3 domain superfamily

  2. XM_042332703.1 → XP_042188637.1  tight junction protein ZO-2a isoform X3

    UniProtKB/TrEMBL
    A0A4W3I2J6, A0A4W3I740
    Conserved Domains (5) summary
    smart00072
    Location:634 → 809
    GuKc; Guanylate kinase homologues
    smart00228
    Location:242 → 313
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam17069
    Location:124 → 223
    RSRP; Arginine/Serine-Rich protein 1
    cl17036
    Location:534 → 600
    SH3; Src Homology 3 domain superfamily

  3. XM_007892652.2 → XP_007890843.1  tight junction protein ZO-2a isoform X2

    See identical proteins and their annotated locations for XP_007890843.1

    UniProtKB/TrEMBL
    A0A4W3I2J6, V9K9U3
    Related
    ENSCMIP00000022943.1
    Conserved Domains (4) summary
    smart00072
    Location:644 → 819
    GuKc; Guanylate kinase homologues
    smart00228
    Location:252 → 323
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:19 → 104
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl17036
    Location:544 → 610
    SH3; Src Homology 3 domain superfamily

  4. XM_007892655.2 → XP_007890846.1  tight junction protein ZO-2a isoform X3

    See identical proteins and their annotated locations for XP_007890846.1

    UniProtKB/TrEMBL
    A0A4W3I2J6, A0A4W3I740
    Related
    ENSCMIP00000022962.1
    Conserved Domains (5) summary
    smart00072
    Location:634 → 809
    GuKc; Guanylate kinase homologues
    smart00228
    Location:242 → 313
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam17069
    Location:124 → 223
    RSRP; Arginine/Serine-Rich protein 1
    cl17036
    Location:534 → 600
    SH3; Src Homology 3 domain superfamily

  5. XM_007892651.2 → XP_007890842.1  tight junction protein ZO-2a isoform X1

    UniProtKB/TrEMBL
    A0A4W3I2J6
    Conserved Domains (4) summary
    smart00072
    Location:645 → 820
    GuKc; Guanylate kinase homologues
    smart00228
    Location:253 → 324
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:20 → 105
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl17036
    Location:545 → 611
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein
Heading Accession and Version

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