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PSEN2 presenilin 2 [ Physeter catodon (sperm whale) ]

Gene ID: 102973884, updated on 10-Mar-2024

Summary

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Gene symbol
PSEN2
Gene description
presenilin 2
See related
Ensembl:ENSPCTG00005001191
Gene type
protein coding
RefSeq status
MODEL
Organism
Physeter catodon
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Physeteridae; Physeter
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_04 current ASM283717v5 (GCF_002837175.3) 4 NC_041217.1 (24734439..24760581, complement)
102 previous assembly ASM283717v2 (GCF_002837175.2) 4 NC_041217.1 (24719596..24760581, complement)

Chromosome 4 - NC_041217.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114486115 Neighboring gene inositol-trisphosphate 3-kinase B Neighboring gene uncharacterized LOC114486116 Neighboring gene uncharacterized LOC114485995 Neighboring gene uncharacterized LOC114486117 Neighboring gene CDC42 binding protein kinase alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables aspartic endopeptidase activity, intramembrane cleaving IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch receptor processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in amyloid precursor protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in amyloid-beta metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in ciliary rootlet IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in dendritic shaft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
presenilin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002837175.3-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM283717v5 Primary Assembly

Genomic

  1. NC_041217.1 Reference ASM283717v5 Primary Assembly

    Range
    24734439..24760581 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028488392.2 → XP_028344193.1  presenilin-2 isoform X3

    UniProtKB/TrEMBL
    A0A2Y9TCD4
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 438
    Presenilin

  2. XM_024130722.3 → XP_023986490.1  presenilin-2 isoform X3

    UniProtKB/TrEMBL
    A0A2Y9TCD4
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 438
    Presenilin

  3. XM_028488388.2 → XP_028344189.1  presenilin-2 isoform X1

    UniProtKB/TrEMBL
    A0A455B6E1
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 437
    Presenilin

  4. XM_028488391.2 → XP_028344192.1  presenilin-2 isoform X2

    UniProtKB/TrEMBL
    A0A455BJV5
    Related
    ENSPCTP00005001626.1, ENSPCTT00005001783.1
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 406
    Presenilin

  5. XM_028488393.2 → XP_028344194.1  presenilin-2 isoform X3

    UniProtKB/TrEMBL
    A0A2Y9TCD4
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 438
    Presenilin

  6. XM_028488395.2 → XP_028344196.1  presenilin-2 isoform X5

    UniProtKB/TrEMBL
    A0A455BJW0
    Conserved Domains (1) summary
    pfam01080
    Location:1 → 349
    Presenilin

  7. XM_028488394.1 → XP_028344195.1  presenilin-2 isoform X4

    UniProtKB/TrEMBL
    A0A455B5I4
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 335
    Presenilin

RNA

  1. XR_003679357.2 RNA Sequence

  2. XR_008617039.1 RNA Sequence

  3. XR_003679358.2 RNA Sequence

Nucleotide Protein
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