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MET MET proto-oncogene, receptor tyrosine kinase [ Panthera tigris (tiger) ]

Gene ID: 102953616, updated on 11-Apr-2024

Summary

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Gene symbol
MET
Gene description
MET proto-oncogene, receptor tyrosine kinase
Gene type
protein coding
RefSeq status
MODEL
Organism
Panthera tigris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Pantherinae; Panthera
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: A2
Exon count:
24
Annotation release Status Assembly Chr Location
102 current P.tigris_Pti1_mat1.1 (GCF_018350195.1) A2 NC_056661.1 (133680067..133825798)

Chromosome A2 - NC_056661.1Genomic Context describing neighboring genes Neighboring gene caveolin 2 Neighboring gene caveolin 1 Neighboring gene U2 spliceosomal RNA Neighboring gene capping actin protein of muscle Z-line subunit alpha 2 Neighboring gene suppression of tumorigenicity 7

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056661.1 Chromosome A2 Reference P.tigris_Pti1_mat1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables semaphorin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in semaphorin-plexin signaling pathway involved in axon guidance IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of semaphorin receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
hepatocyte growth factor receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Panthera tigris Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference P.tigris_Pti1_mat1.1 Primary Assembly

Genomic

  1. NC_056661.1 Reference P.tigris_Pti1_mat1.1 Primary Assembly

    Range
    133680067..133825798
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015540681.2 → XP_015396167.1  hepatocyte growth factor receptor

    Conserved Domains (6) summary
    smart00423
    Location:520 → 562
    PSI; domain found in Plexins, Semaphorins and Integrins
    smart00429
    Location:839 → 935
    IPT; ig-like, plexins, transcription factors
    cd01180
    Location:564 → 657
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd05058
    Location:1083 → 1344
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    cl15674
    Location:743 → 838
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    cl15693
    Location:25 → 517
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

RNA

  1. XR_006212123.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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