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actn2 actinin alpha 2 [ Lepisosteus oculatus (spotted gar) ]

Gene ID: 102682600, updated on 2-Nov-2023

Summary

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Gene symbol
actn2
Gene description
actinin alpha 2
See related
Ensembl:ENSLOCG00000016619
Gene type
protein coding
RefSeq status
MODEL
Organism
Lepisosteus oculatus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae; Lepisosteus
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Genomic context

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Location:
chromosome: LG16
Exon count:
25
Annotation release Status Assembly LG Location
101 current LepOcu1 (GCF_000242695.1) LG16 NC_023194.1 (16262019..16295634, complement)

Linkage Group LG16 - NC_023194.1Genomic Context describing neighboring genes Neighboring gene ryanodine receptor 2a (cardiac) Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase Neighboring gene HEAT repeat containing 1 Neighboring gene arginase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_023194.1 Chromosome LG16 Reference LepOcu1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in muscle cell development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
alpha-actinin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Lepisosteus oculatus Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference LepOcu1 Primary Assembly

Genomic

  1. NC_023194.1 Reference LepOcu1 Primary Assembly

    Range
    16262019..16295634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006638666.2 → XP_006638729.1  alpha-actinin-2 isoform X4

    UniProtKB/TrEMBL
    W5NIS0
    Related
    ENSLOCP00000020531.1, ENSLOCT00000020566.1
    Conserved Domains (7) summary
    smart00033
    Location:47 → 144
    CH; Calponin homology domain
    COG5126
    Location:754 → 898
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00014
    Location:156 → 261
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:761 → 823
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:406 → 633
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:285 → 394
    Spectrin; Spectrin repeat
    pfam08726
    Location:828 → 894
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  2. XM_006638665.2 → XP_006638728.1  alpha-actinin-2 isoform X3

    UniProtKB/TrEMBL
    W5NIS0
    Related
    ENSLOCP00000020529.1, ENSLOCT00000020564.1
    Conserved Domains (7) summary
    smart00033
    Location:47 → 144
    CH; Calponin homology domain
    COG5126
    Location:754 → 898
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00014
    Location:156 → 261
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:761 → 823
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:406 → 633
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:285 → 394
    Spectrin; Spectrin repeat
    pfam08726
    Location:828 → 894
    EFhand_Ca_insen; Ca2+ insensitive EF hand

  3. XM_015363149.1 → XP_015218635.1  alpha-actinin-2 isoform X2

    UniProtKB/TrEMBL
    W5NIS2
    Conserved Domains (5) summary
    smart00033
    Location:3 → 68
    CH; Calponin homology domain
    cd00014
    Location:80 → 185
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:330 → 557
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:209 → 318
    Spectrin; Spectrin repeat
    cl08302
    Location:685 → 714
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  4. XM_015363148.1 → XP_015218634.1  alpha-actinin-2 isoform X1

    UniProtKB/TrEMBL
    W5NIS2
    Conserved Domains (5) summary
    smart00033
    Location:3 → 68
    CH; Calponin homology domain
    cd00014
    Location:80 → 185
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:330 → 557
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:209 → 318
    Spectrin; Spectrin repeat
    cl08302
    Location:685 → 714
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein
Heading Accession and Version

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