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Ano10 anoctamin 10 [ Mus musculus (house mouse) ]

Gene ID: 102566, updated on 18-Sep-2024

Summary

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Official Symbol
Ano10provided by MGI
Official Full Name
anoctamin 10provided by MGI
Primary source
MGI:MGI:2143103
See related
Ensembl:ENSMUSG00000037949 AllianceGenome:MGI:2143103
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem16k
Summary
This gene encodes a member of the anoctamin family, which in mammals is comprised of 10 members. Anoctamin proteins are proposed to have eight transmembrane domains with both termini facing the cytoplasm and a C-terminal domain of unknown function. While some members have been characterized as calcium-activated chloride channels, this protein is reported to inhibit anion conductance. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Dec 2012]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 24.2), subcutaneous fat pad adult (RPKM 23.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F4; 9 72.94 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (122004958..122123440, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (122175874..122294444, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39465 Neighboring gene predicted gene, 39464 Neighboring gene STARR-seq mESC enhancer starr_25542 Neighboring gene STARR-seq mESC enhancer starr_25543 Neighboring gene SNF related kinase Neighboring gene predicted gene, 57550 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:122142092-122142320 Neighboring gene STARR-seq mESC enhancer starr_25545 Neighboring gene microRNA 8106 Neighboring gene STARR-positive B cell enhancer ABC_E574 Neighboring gene predicted gene, 26797 Neighboring gene predicted gene, 35289

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TMEM16K is an interorganelle regulator of endosomal sorting. Petkovic M, et al. Nat Commun, 2020 Jul 3. PMID 32620747, Free PMC Article
  2. Predominant localization of phosphatidylserine at the cytoplasmic leaflet of the ER, and its TMEM16K-dependent redistribution. Tsuji T, et al. Proc Natl Acad Sci U S A, 2019 Jul 2. PMID 31217287, Free PMC Article
  3. Cellular defects by deletion of ANO10 are due to deregulated local calcium signaling. Wanitchakool P, et al. Cell Signal, 2017 Jan. PMID 27838374
  4. Anoctamins support calcium-dependent chloride secretion by facilitating calcium signaling in adult mouse intestine. Schreiber R, et al. Pflugers Arch, 2015 Jun. PMID 24974903
  5. Expression and functional significance of the Ca(2+)-activated Cl(-) channel ANO6 in dendritic cells. Szteyn K, et al. Cell Physiol Biochem, 2012. PMID 23159814

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TMEM16K is an interorganelle regulator of endosomal sorting.
    Title: TMEM16K is an interorganelle regulator of endosomal sorting.
  2. mediates Ca2+-dependent phosphatidylserine scrambling in the endoplasmic reticulum
    Title: Predominant localization of phosphatidylserine at the cytoplasmic leaflet of the ER, and its TMEM16K-dependent redistribution.
  3. mutations in ANO10 cause cellular defects and genetic disorders through deranged local Ca(2+) signaling.
    Title: Cellular defects by deletion of ANO10 are due to deregulated local calcium signaling.
  4. Ano10 is essential for Ca2+-dependent Cl- secretion in jejunum.
    Title: Anoctamins support calcium-dependent chloride secretion by facilitating calcium signaling in adult mouse intestine.
  5. during mouse cephalic development: detected in subventricular zone and differentiating fields, In organs developing through epithelial-mesenchymal interactions, such as the palate, tooth and tongue
    Title: Expression patterns of the Tmem16 gene family during cephalic development in the mouse.
  6. Data show the expression of Tmem16k during murine embryogenesis with an emphasis on the respiratory, digestive, skeletal, and integumentary systems.
    Title: Expression of TMEM16 paralogs during murine embryogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC106272

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium-activated cation channel activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium-activated cation channel activity ISO
Inferred from Sequence Orthology
more info
  
enables chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables intracellularly calcium-gated chloride channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables intracellularly calcium-gated chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
enables intracellularly calcium-gated chloride channel activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables phospholipid scramblase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in chloride transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
anoctamin-10
Names
transmembrane protein 16K

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271873.2 → NP_001258802.1  anoctamin-10 isoform 2

    See identical proteins and their annotated locations for NP_001258802.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site in the coding region, compared to variant 1. The resulting isoform (2) spans the membrane six times (rather than eight as in isoform 1) and is shorter than isoform 1.
    Source sequence(s)
    AC120394, AC121264
    Consensus CDS
    CCDS90687.1
    UniProtKB/Swiss-Prot
    Q8BH79
    Related
    ENSMUSP00000151189.2, ENSMUST00000214409.2
    Conserved Domains (1) summary
    pfam04547
    Location:197 → 570
    Anoctamin; Calcium-activated chloride channel

  2. NM_001421547.1 → NP_001408476.1  anoctamin-10 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC121264
    Related
    ENSMUSP00000150161.2, ENSMUST00000216670.2

  3. NM_001421549.1 → NP_001408478.1  anoctamin-10 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC120394, AC121264

  4. NM_001421551.1 → NP_001408480.1  anoctamin-10 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC121264
    UniProtKB/TrEMBL
    A0A1L1SV36
    Related
    ENSMUSP00000151030.2, ENSMUST00000214507.2

  5. NM_001421552.1 → NP_001408481.1  anoctamin-10 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC120394, AC121264
    UniProtKB/TrEMBL
    A0A1L1SV36

  6. NM_133979.4 → NP_598740.1  anoctamin-10 isoform 1

    See identical proteins and their annotated locations for NP_598740.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC120394, AC121264
    Consensus CDS
    CCDS23645.1
    UniProtKB/Swiss-Prot
    Q4FZD2, Q8BH79, Q8BMS8, Q8BV74, Q8BW67, Q8R0U0, Q99LP0
    Related
    ENSMUSP00000045214.3, ENSMUST00000042546.4
    Conserved Domains (1) summary
    pfam04547
    Location:200 → 628
    Anoctamin; Calcium-activated chloride channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    122004958..122123440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BH79.1 GenPept UniProtKB/Swiss-Prot:Q8BH79

Gene LinkOut

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