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SMURF2 SMAD specific E3 ubiquitin protein ligase 2 [ Latimeria chalumnae (coelacanth) ]

Gene ID: 102353199, updated on 2-May-2024

Summary

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Gene symbol
SMURF2
Gene description
SMAD specific E3 ubiquitin protein ligase 2
See related
Ensembl:ENSLACG00000014496
Gene type
protein coding
RefSeq status
MODEL
Organism
Latimeria chalumnae
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Coelacanthiformes; Coelacanthidae; Latimeria
Orthologs
human zebrafish all
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Genomic context

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Location:
chromosome: 18
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_04 current fLatCha1.pri (GCF_037176945.1) 18 NC_088156.1 (11435720..11508886)
101 previous assembly LatCha1 (GCF_000225785.1) Unplaced Scaffold NW_005819190.1 (1039408..1107786)

Chromosome 18 - NC_088156.1Genomic Context describing neighboring genes Neighboring gene transfer RNA arginine (anticodon CCG) Neighboring gene karyopherin alpha 2 (RAG cohort 1, importin alpha 1) Neighboring gene centrosomal protein of 95 kDa Neighboring gene DEAD (Asp-Glu-Ala-Asp) box helicase 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase SMURF2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_037176945.1-RS_2024_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference fLatCha1.pri

Genomic

  1. NC_088156.1 Reference fLatCha1.pri

    Range
    11435720..11508886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005993725.3 → XP_005993787.1  E3 ubiquitin-protein ligase SMURF2

    UniProtKB/TrEMBL
    H3B3I0
    Related
    ENSLACP00000016451.2
    Conserved Domains (5) summary
    cd08382
    Location:13 → 137
    C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
    smart00456
    Location:298 → 330
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:426 → 751
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:399 → 751
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:159 → 188
    WW; WW domain
Nucleotide Protein
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